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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue:2010, vol. 16, book 3
Subject Collection: Medicine
Page: 8 - 10
DOI:10.5272/jimab.1632010_8-10
Online date: July 05, 2010
J of IMAB 2010; 16(3):8-10
YKL-40 – A NEW DIAGNOSTIC BIOMARCER FOR BENIGN BREAST DISEASES AND BREAST CANCER
Vanya Uzunova1, G. Paskalev1, Maria Kazakova3, E. Poryazova2, K. Murdjev1, A. Uchikov1, A. Iankulov1, Victoria Sarafian3, D. Manolova5, A. Paskaleva4, B. Hadjiev1, J. Grudeva-Popova6
1) Clinic of Thoracic and Abdominal Surgery, 2) Department of Common and Clinical Pathology, 3) Department of Biology, 4) Clinic of Dermatologic and Veneric Diseases, 5) Department of Diagnostic Imaging, 6) Department of Oncology and Haematology,
Medical University - Plovdiv, Bulgaria
ABSTRACT:
Benign breast diseases encompass a wide spectrum of lesions, which raise a lot of questions about their classification, diagnosis, prognosis and surgical treatment.
The aim of this study is to measure the serum level of YKL-40 in cases of different groups of benign breast diseases, to compare it to the level of healthy women as well as to those with breast cancer and to examine its tissue expression after surgical treatment. We use it as a diagnostic marker and as a criterion for differential diagnosis.
Forty nine (49) patients with benign breast diseases and twenty (20) patients with breast cancer were examined. All of them had their serum level of YKL-40 measured preoperatively and its tissue expression examined immunohystochemically after the surgical intervention. There were significant differences in both concentration and tissue expression of this marker in patients with different groups of benign breast diseases and breast cancer. YKL-40 can be an important biomarker in the diagnosis and differential diagnosis of breast diseases.
Key words: breast, YKL-40, benign diseases, biomarker.
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Please cite this article as: Uzunova V, Paskalev G, Kazakova M, Poryazova E, Murdjev K, Uchikov A, Iankulov A, Sarafian V, Manolova D, Paskaleva A, Hadjiev B, Grudeva-Popova J. YKL-40 – A NEW DIAGNOSTIC BIOMARCER FOR BENIGN BREAST DISEASES AND BREAST CANCER. J of IMAB. 2010; 16(3):8-10. doi: http://dx.doi.org/10.5272/jimab.1632010_8-10.
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