back to 2010, vol. 16, b. 3

Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski PubLishing
ISSN: 1312 773X (Online)
Issue: 2010, vol. 16, book 3
Subject Collection: Medicine
Page: 61 - 65
DOI: 10.5272/jimab.1632010_61
Online date: February 2, 2010

J of IMAB 2010; 16(3):61-65
SOME PSYCHOPATHOLODICAL PECULIARITIES AT EARLY AND LATE ONSET IN PATIENTS WITH ALZHEIMER'S DISEASE

Mariana Arnaoudova
Third Psychiatric Clinic, MHAT “St. Marina”, Department of Psychiatry, Medical University, Varna, Bulgaria

ABSTRACT:
Age-related conditions are of great medical and social importance. The most common cause of dementia is Alzheimer’s disease (AD). Neuropsychiatric symptoms are an integral part of the disease and present severe problems to patients, their families, caregivers and the society at large.
The aim of our work was to explore the manifestation of some psychic (non-psychotic and psychotic) and behavioral symptoms (BPSD) of hospitalized  patients with early onset (EO-AD) and late onset (LO-AD) of AD with a view to compare and enrich the clinical, diagnostic and differential diagnostic possibilities. In this study significant differences in terms of BPSD between EO-AD and LO-AD patients were found. The data of EO-AD patients to be more psychotic with more behavioral problems could represent another clinical support of dividing AD not only to the age of onset.
As we discuss in our paper some methodological issues, the number of examined patients in our study was comparatively small. That is why we comment some of the data as a tendency.

Key words:  early onset Alzheimer’s disease (EO-AD), late onset Alzheimer’s disease (LO-AD), BPSD, in-patients,

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REFERENCES:
1. Ballard C, Oyebode F. Psychotic symptoms in patients with dementia. Int J Geriatr Psychiatry 1995; 10: 743-752.
2. Balestreri L, Grossberg A, Grossberg GT. Behavioral and Psychological Symptoms of Dementia as a Risk factor for Nursing Home Placement. International Psychogeriatrics 2000; 12(Supll.S1): 59-62. [CrossRef]
3. Bylsma FW,  Folstein M,  Devanand DP et al. Delusions and patterns of cognitive impairment in Alzheimer’s disease. Neuropsychiatry Neuropsychol Behav Neurol 1994; 7: 98-103.
4. Chemerinski E, Petracca G, Teson A. Sabe L, Leiguarda R, Starkstein SE. Prevalence and correlates of aggressive behavior in Alzheimer’s disease. J Neuro­psychiatry Clin Neurosci Nov. 1998; 10:421-5.
5. Cummings JL, Mega MS, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J.. The Neuropsychiatric Inventory: Comprehensive assessment of psycho­pathology in dementia. Neurology 1994; Dec;44(12): 2308-2314. [PubMed]
6. de Medeiros K, Robert P, Gauthier S, Stella F, Politis A, Leoutsakos J, et al. The Neuropsychiatric Inventory-Clinician rating scale (NPI-C): reliability and validity of a revised assessment of neuropsychiatric symptoms in dementia. Int Psychogeriatr. 2010 Sep;22(6):984-94. Epub 2010 Jul 1.. [PubMed]
7. Ferran J, Wilson K, Doran M et al. The early onset dementias: a study of clinical characteristics and service use. Int J Geriatr Psychiatry 1996; 11: 863-869.
8. Finkel S. Behavioral and psycho­logical signs and symptoms of dementia: Implications for research and treatment. Int Psychogeriatr  1996; /Suppl. 3/: 215-552.
9. Finkel S, Burns A. Behavioral and Psychological symptoms of Dementia /BPSD/: A Clinical and Research Update. Introduction. Int Psychogeriatr 2000; 12 /Suppl. 1/: 9-12.
10. Finkel S, Burns A, Cohen G. Behavioral and Psychological symptoms of Dementia /BPSD/: A Clinical and Research Update. Overview. Int Psychogeriatr 2000; 12 /Suppl. 1/:13-18.
11. Flynn FG, Cummings JL, Gornbein J. Delusions in dementia syndromes: investigation of behavioral and neuropsychological correlates. J Neuro­psychiatry Clin Neurosci 1991; 3(4): 364-70. [PubMed]
12. Folstein MR, Folstein SE, McHugh PR. ”Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; Nov;12(3):189-198. [PubMed]
13. Fujimory M, Immamura T, Yamashita H, et al. Age at onset and visuocognitive disturbances in Alzheimer’s disease. Alzheimer Dis Assoc Disord 1998; Sep;12(3):163-166. [PubMed]
14. Hargrave R, Reed B, Mungas D. Depressive syndromes and functional disability in dementia. J Geriatr Psychiatry Neurol 2000; 13: 72-7. [PubMed]
15. Holtzer R, Tang MX, Devanand DP et al. Psychopathological features in Alzheimer’s disease: course and relationship with cognitive status. J Am Geriatr Soc 2003; 51: 953–60. [CrossRef]
16. Imamura T, Takatsuki Y, Fujimory M, et al. Age at onset and language disturbances in Alzheimer’s disease. Neuropsychologia 1998; Sep;36(9):945-949. [PubMed]
17. Jacobs D, Sano M, Marder K, et al. Age at onset of Alzheimer’s disease: relation to pattern of cognitive dysfunction and rate of decline. Neurology 1994; Jul;44(7):1215-1220. [PubMed] .
18. Janzing J, Naarding P, Eling P. Depressive Symptoms Predict Slow Cognitive Decline in Mild Dementia. Dementia Geriatr Cogn Disord 2005;20:(2-3)77-81 [PubMed]
19. Jeffry S. Depression Doubles Risk for Dementia and Alzheimer’s disease. Neurology 2010; 75: 35-41, 27-34, 21-26, 12-14.
20. Jeste D, Finkel, S. Psychosis of Alzheimer’s disease and related dementia. Am J Geriatr Psychiatry 2000; 8: 29-34. [PubMed]
21. Jeste DV, Wragg RE, Salmon DP, Harris MJ, Thal LJ. Cognitive deficits of patients with Alzheimer’s disease with and without delusions. Am J Psychiatry 1992; Feb;149(2):184-9. [PubMed]
22. Lawlor BA, Swanwick G, Coen R. Relationship Between Cognition and Behavioral and Psychological Symptoms of Dementia. International Psychogeriatrics 2000; 12 /Suppl.S1/:165-170. [CrossRef]

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