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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2010, vol. 16, book 3
Subject Collection: Medicine
Page: 3 - 7
DOI: 10.5272/jimab.1632010_3-7
Online date: July 05, 2010
J of IMAB 2010; 16(3):3-7
YKL-40 IN SERA OF BREAST TUMOR PATIENTS
Maria Kazakova1, Tanya Deneva2, Vanya Uzunova3, Victoria Sarafian1
1) Department of Medical Biology; 2) Department of Clinical Laboratory; 3) Clinic of Thoraco-Abdominal Surgery;
Medical University - Plovdiv, Bulgaria.
ABSTRACT:
YKL-40, also known as human cartilage glycoprotein 39, is a member of the “mammalian chitinase-like proteins”, but lacking of chitinase activity. Increased variations in serum concentrations are associated with inflammatory processes and several types of cancer.
In this study we evaluated serum YKL-40 levels in healthy controls and in women with benign and malignant breast tumors.
YKL-40 serum levels were measured by enzyme-linked immunosorbent assay – ELISA in 32 patients. The effect of the various factors was analyzed using correlation and regression analyses simultaneously determining the size and direction of correlation. The level of statistical significance of null hypothesis was P<0.05.
Our study showed that serum YKL-40 level in breast carcinoma was significantly higher than the concentration in healthy controls (p<0.01). The changes in protein levels were higher than 25%. Serum YKL-40 increased with age (rxy=0.46). The correlation between glycoprotein quantity and age was positive, but feeble.
This investigation is first in Bulgaria to demonstrate significantly elevated serum YKL-40 level in breast carcinoma compared to women with benign breast tumors and healthy controls. Longitudinal studies are needed to confirm YKL-40 as a potential and reliable biomarker.
Key words: YKL-40, ELISA, breast tumor.
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Please cite this article as: Kazakova M, Deneva T, Uzunova V, Sarafian V. YKL-40 IN SERA OF BREAST TUMOR PATIENTS. J of IMAB. 2010; 16(3):3-7. doi: 10.5272/jimab.1632010_3-7.
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