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Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312-773X (Online)
Issue: 2009, Volume 15, book 2
Subject Collection: Medicine
Page: 6 - 9
DOI: 10.5272/jimab.1522009_6
Online date: June 12, 2009,
Secretory immunoglobulin A (SIgA) and dental caries of children with different diseases and conditions influencing oral medium
Maya Rashkova*, M. Baleva**, M. Peneva*, N. Toneva*, G. Jegova*
*Department of Paediatric Dentistry, Faculty of Dental Medicine,
** Department of allergology, Laboratory of clinical immunology,
Medical University - Sofia, Bulgaria
Summary:
SIgA is the main type immunoglobulin in the mixed saliva and is considered as the main secretion factor of the adaptive immunity in the mouth. The purpose of the study is an evaluation of the SIgA quantities and the connection of those antibodies with dental caries of children with different diseases and conditions influencing the oral medium. The study was performed with 116 children with diabetes, asthma, orthodontic problems (removable braces) and healthy controls. The following methods were used: (1) ELISA with “Salivary secretory IgA KIT of SalimetricsLLC USA; was used for quantitative determination of IgA-S in the saliva; (2) Evaluation of the liquid oral medium (test “Saliva check-GC”) and dental status (DMF-T) of the children studied.
The results obtained came to show that 2/3 of the healthy children and the children with diabetes have low values of c(<100 мg/ml). In the group of healthy children there are no high values of SIgA; Middle values of SIgA (100 -300 мg/ml) are most frequently met in children with asthmatic disease; Oone half of the children with orthodontic apparatuses have high values of SIgA (>300 мg/ml); There is no dependence between secretory immunity and dental caries in children.
Key words: secretory IgA-antibodies, oral homeostasis, dental biofilm, diabetes, asthma, orthodontic treatment, dental caries, DMF
Page: 6-9; FULL TEXT PDF (213 KB)