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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2007, vol. 13, book 1
Subject Collection: Medicine
Page: 71-73
DOI: 10.5272/jimab.2007131.67
Online date: November 15, 2007
J of IMAB 2007; 13(1):71-73
GEMCITABINE/CISPLATIN CONTAINING CHEMOTHERAPY IN PATIENTS WITH STAGE III-IV NON SMALL CELL LUNG CANCER
Deyan N. Davidov,
Department of chemotherapy, Oncological center, Medical University - Pleven, Bulgaria
ABSTRACT:
Backgraund: A two- drug platinum- based regimens is the standard first- line treatment for inoperable non- small cell lung cancer /NSCLC/ patients with perfomance status /PS/ 0-2. The aim of this study was to evaluate the efficacy and safety of chemotherapy combination Gemcitabine- cis-Platinum in patients with advanced NSCLC. Methods: Thirty-four patients with unresectable, histologically proven stage III/IV NSCLC entered the study. Chemotherapy consist of Gemcitabine 1250 mg/m 2 on day 1 and 8 and CDDP 80 mg/m 2 with hyperhydration on day 1 with repetition after 21 days until progression. Results: One complete response and eleven partial response was obtained. The main grade toxicity included neutropenia, thrombocytopenia, nausea/vomiting, neuropathy. Conclusions: Gemcitabine/CDDP were feasible and effective in stage III/IV NSCLC patients with 35.5% response rate and mild to moderate toxicity.
Key words: Gemcitabine, Non small cell lung cancer, Response rate.
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Please cite this article as:
Davidov DN. GEMCITABINE/CISPLATIN CONTAINING CHEMOTHERAPY IN PATIENTS WITH STAGE III-IV NON SMALL CELL LUNG CANCER. J of IMAB. 2007; 13(1):71-73. doi: 10.5272/jimab.2007131.67
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