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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2006, vol. 12, issue 1
Subject Collection: Medicine
Page: 41-46
DOI: 10.5272/jimab.2006121.41
Online date: November 4, 2006
J of IMAB 2006; 12(1):41-46
CNS GERMINOMA WITH SYNCHRONOUS LESIONS IN THE SUPRASELLAR AND PINEAL REGIONS: CLINICAL, CT AND IMMUNOLOGICAL FOLLOW-UP.
Ara G. Kaprelyan1, Nadejda Deleva1, Alexandra Tzoukeva1, B. Balev2, Krassimir T. Metodiev3, George N. Kyuchukov4
1) Department of Neurology; 2) Department of Radiology; 3) Department of Microbiology; 4)Department of Neurosurgery;
Medical University of Varna, Bulgaria.
ABSTRACT:
Germinomas are the most frequent type of germ cell tumors that constitute only 2-5% of all central nervous system malignancies. Most of them arise in the pineal and suprasellar regions but in about 5% to 10% the simultaneous location is found. Although their strategic location, they respond well to surgery, radiation and chemotherapy and the prognosis is very good. We report a case of 23-years young male presented with gait disturbance, weakness in lower extremities, visual impairment and moderate fatigue. His medical history revealed that he was symptomatic by DI (polyuria, polydypsia and weight loss) and received treatment with adiuretin for a period of 3 years. Computed tomography (CT) scans demonstrated well circumscribed tumor lesions with a homogeneous contrast enhancement in the suprasellar and pineal regions. A germinoma was verified histologically. A good treatment response to surgery, radiation, chemotherapy and management of endocrine insufficiency was achieved. The postoperative neurological, CT and immunological follow-up corresponded with the clinical course of the disease and the results of therapeutic procedures.
Key words: germinoma, synchronous location, clinical presentation, CT imaging, immunological monitoring.
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Please cite this article as:
Kaprelyan AG, Deleva N, Tzoukeva A, Balev B, Metodiev KT, Kyuchukov GN. CNS GERMINOMA WITH SYNCHRONOUS LESIONS IN THE SUPRASELLAR AND PINEAL REGIONS: CLINICAL, CT AND IMMUNOLOGICAL FOLLOW-UP. J of IMAB. 2006; 12(1):41-46; DOI:10.5272/jimab.2006121.41
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