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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2025, vol. 31, issue1
Subject Area: Medicine
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DOI: 10.5272/jimab.2025311.6009
Published online: 17 Febrary 2025
Original article
J of IMAB. 2025 Jan-Mar;31(1):6009-6012
PSA DENSITY - A MARKER FOR POORLY-DIFFERENTIATED PROSTATE CANCER
Tosho Ganev
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Clinic of Urology, Department of Urology, Faculty of Medicine, MHAT "Sveta Anna-Varna", Medical University-Varna, Bulgaria.
ABSTRACT:
Purpose: The present study examines the relationship between Prostate-Specific Antigen Density (PSAD) and the degree of differentiation of prostate cancer, as determined by the Gleason score.
Material/Methods: A single-center study was conducted. We analyzed 155 patients who had had surgeries at the Urology Clinic of Saint Anna Hospital in Varna.
Results: We found that an elevated PSAD - especially above 0.15 ng/ml2 – increases the probability of detecting a poorly-differentiated cancer (with a high Gleason score) with unfavorable features from the pathological report after the radical prostatectomy (seminal vesicle involvement, lymph node metastases and extraprostatic tumor extension).
Conclusions: PSAD is a valid tool which correctly predicts the unfavorable pathology of the removed specimen.
Keywords: Prostate-specific antigen, prostate volume, Gleason score,
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Please cite this article as: Ganev T. PSA density - a marker for poorly-differentiated prostate cancer. J of IMAB. 2025 Jan-Mar;31(1):6009-6012. [Crossref - 10.5272/jimab.2025311.6009]
Correspondence to: Tosho Ganev, Multiprofile Hospital for Active Treatment "Sveta Anna-Varna"- Clinic of urology, Medical University-Varna, Department of urology; 100, Tzar Osvoboditel Blvd., Varna, 9000, Bulgaria; E-mail: dr_ganev@yahoo.comm
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Received: 13 September 2024
Published online: 17 February 2025