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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2024, vol. 30, issue4
Subject Area: Medicine
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DOI: 10.5272/jimab.2024304.5925
Published online: 13 December 2024
Review article
J of IMAB. 2024 Oct-Dec;30(4):5925-5930
ROLE OF SOME MICRONUTRIENTS IN THE HEALING PROCESS OF DIABETIC ULCERS
Minka Hristova
, Antoniya Hachmeriyan,
Department of Physiology and Pathophysiology, Faculty of Medicine, Medical University Varna, Bulgaria.
ABSTRACT:
Background: Diabetic foot ulcer (DFU) is among the most serious and traumatic complications of diabetes mellitus. Nutrition is essential in chronic wound healing as extra nutrients, including micronutrients, are often needed for proper tissue repair. We aim to examine and analyze the relationship between oral intake of some micronutrients and wound healing in patients with DFU.
Methods: A search was conducted in the Medline/Pubmed and Google Scholar databases, using comprehensive keywords, and articles published in the last 10 years were analyzed.
Review Results: Minerals represent an essential factor in the multifaceted wound healing process. Micronutrient deficiency affects all phases of wound healing, including collagen synthesis, fibroblast proliferation, and epithelization. Magnesium, zinc, selenium, and copper have been postulated as beneficial for DFU as they function as antioxidants modulate immunity, cell replication and differentiation, and tissue repair.
Conclusion: More research is needed to clarify and warrant the use of mineral supplementation for the prevention and healing of diabetic foot ulcers.
Keywords: micronutrients, diabetic foot ulcer, supplementation,
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Please cite this article as: Hristova M, Hachmeriyan A. Role of some micronutrients in the healing process of diabetic ulcers. J of IMAB. 2024 Oct-Dec;30(4):5925-5930.
[Crossref - 10.5272/jimab.2024304.5925]
Correspondence to: Minka Hristova Aleksandrova, Department of Physiology and Pathophysiology, Faculty of Medicine, Medical University of Varna; 55, Marin Drinov Str., 9002 Varna, Bulgaria; E-mail: hristova.minka@abv.bg
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Received: 31 July 2024
Published online: 13 December 2024