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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2024, vol. 30, issue4
Subject Area: Medicine
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DOI: 10.5272/jimab.2024304.5910
Published online: 06 December 2024
Original article
J of IMAB. 2024 Oct-Dec;30(4):5910-5915
PREDICTORS OF MORTALITY AMONG DEPRESSIVE PATIENTS WITH HFPEF, HFMEF, HFREF
Ralitsa Pancheva
, Ventsislava Pencheva, Emil Manov, Vasil Kolev, Blagovest Stoimenov
,
Department of Propaedeutics of Internal Diseases, UMHAT "Alexandrovska"; Medical Faculty, Medical University - Sofia, Bulgaria.
ABSTRACT:
Background: Heart failure patients accompany heightened risks of depression. The coexistence of these diseases not only increases mortality rates but also leads to more frequent hospitalizations.
Aim: This study aims to analyze prognostic factors in hospitalized HF patients with depression.
Materials and methods: A single-center cohort study enrolled HF patients admitted between January 2019 and January 2022. Tests for depression (Hamilton Depression Rating Scale; HAM-D) were performed on all participants.
Results: The study cohort comprised 114 patients with an average age of 70.6 ± 9.6 years. Most patients were classified as New York Heart Association (NYHA) Class II/III prior to the index admission, and around 60% exhibited a left ventricular ejection fraction (LVEF) above 50%. Depression severity varied across HF subgroups. CAD and secondary pulmonary hypertension are crucial in determining the prognosis of patients with HF with preserved (HFpEF) and reduced ejection fraction (HFrEF). Anemia is a common factor increasing mortality in HFpEF and with HF with mid-range ejection fraction (HFmEF). Diabetes, especially insulin-dependent, affects survival in patients with HFpEF, while it does not impact prognosis in other subgroups. Advanced age and chronic kidney disease are determining factors for survival in patients with HFpEF. Atrial fibrillation, alcohol abuse and previous stroke are factors associated with higher mortality in patients with HFmEF.
Conclusions: This study provides valuable insights for clinicians, aiding in the identification of high-risk patients and the implementation of proactive measures for their management, thereby improving the care of HF patients with depression.
Keywords: Depression, mortality, predictors, heart failure, ejection fraction,
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Please cite this article as: Pancheva R, Pencheva V, Manov E, Kolev V, Stoimenov B. Predictors of mortality among depressive patients with HFpEF, HFmEF, HFrEF. J of IMAB. 2024 Oct-Dec;30(4):5910-5915. [Crossref - 10.5272/jimab.2024304.5910]
Correspondence to: Blagovest Stoimenov, Department of Propaedeutics of Internal Diseases, UMHAT "Alexandrovska"; Medical Faculty, Medical University - Sofia; 1, St Georgi Sofiiski Str., Sofia, Bulgaria; E-mail: stoimenov90@gmail.com
REFERENCES:
1. Duan J, Huang K, Zhang X, Wang R, Chen Z, Wu Z, et al. Role of depressive symptoms in the prognosis of heart failure and its potential clinical predictors. ESC Heart Fail. 2022 Aug;9(4):2676-2685. [PubMed]
2. Grigorov E, Naseva E, Getov I. Study of patients' willingness-to-pay for pharmacotherapy of ischemic heart disease. Arch Balk Med Union. 2011 Sep;46(3):177-179.
3.Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure: a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006;48(8):1527–37. [PubMed]
4. Sokoreli I, Pauws SC, Steyerberg EW, de Vries GJ, Riistama JM, Tesanovic A, et al. Prognostic value of psychosocial factors for first and recurrent hospitalizations and mortality in heart failure patients: insights from the OPERA-HF study. Eur J Heart Fail. 2018 Apr; 20(4): 689–696. [PubMed]
5. O'Connor CM. Depression in heart failure: Beyond a SADHART. JACC Heart Fail. 2018 Oct;6(10):885-886. [PubMed]
6. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2016 Aug;18(8):891–975. [PubMed]
7. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013 Oct 15;62(16):e147-239. [PubMed ]
8. Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, et al. The global health and economic burden of hospitalizations for heart failure: Lessons learned from hospitalized heart failure registries. J Am Coll Cardiol. 2014 Apr 1;63(12):1123-1133. [PubMed]
9. Koehler J, Stengel A, Hofmann T, Wegscheider K, Koehler K, Sehner S, et al. Telemonitoring in patients with chronic heart failure and moderate depressed symptoms: Results of the Telemedical interventional monitoring in heart failure (TIM‐HF) study. Eur J Heart Fail. 2021 Jan;23(1):186-194. [PubMed]
10. Sbolli M, Fiuzat M, Cani D, O'Connor CM. Depression and heart failure: The lonely comorbidity. Eur J Heart Fail. 2020 Nov;22(11):2007-2017. [PubMed]
11. Fan H, Yu W, Zhang Q, Cao H, Li J, Wang J, et al. Depression after heart failure and risk of cardiovascular and all‐cause mortality: a meta‐analysis. Prev Med. 2014 Jun;63:36-42. [PubMed]
12. Freedland KE, Carney RM, Rich MW, Steinmeyer BC, Skala JA, Davila‐Roman VG. Depression and multiple Rehospitalizations in patients with heart failure. Clin Cardiol. 2016 May;39(5):257-62. [PubMed]
13. Diez-Quevedo C, Lupón J, González B, Urrutia A, Cano L, Cabanes R, et al. Depression, antidepressants, and long-term mortality in heart failure. Int J Cardiol. 2013 Aug 20;167(4):1217-25. [PubMed]
14. Dimitrova M, Dilkov D, Marinova Y, Grigorov N. [Associative and family stigma research in people with psychiatric disorders – in benefit of the general practitioners and their patients.] [in Bulgatian] General Medicine. 2020; 22(6):37-44. [Internet]
Received: 30 April 2024
Published online: 06 December 2024