head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2024, vol. 30, issue1
Subject Area: Medicine
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DOI: 10.5272/jimab.2024301.5410
Published online: 07 March 2024

Review article
J of IMAB. 2024 Jan-Mar;30(1):5410-5413
HOW DOES VITAMIN D SUPPLEMENTATION CHANGE THE OUTCOME FOR MOTHER AND CHILD?
Nikolai LazarovORCID logoCorresponding Autoremail, Faisal SaghirORCID logo,
Department of Obstetrics and Gynecology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.

ABSTRACT:
Introduction: Pregnancy represents a period in which rapid bodily changes occur, which include a wide range of physiological interactions occurring in both the mother and the developing foetus. The role of vitamin D3 metabolism within pregnancy is an over-shadowed but very important aspect for the normal and healthy muscoskeletal development of the foetus and for the various alternative functions associated with vitamin D3 for the pregnant female.
The purpose: To provide a detailed understanding ofhe current status of vitamin D3 and the role it has within pregnancy and to identify the efficacy and the wide range of effects that vitamin D3 has for both the mother and foetus.
Materials and methods: We conducted a review of the available literature at PubMed, Google Scholar, and Science Direct, which included observational studies, prospective and controlled trials, reports and guidelines for appropriate dosages of vitamin D3 to be used within pregnant females.
Results and Discussion: Our review of the scientific literature showed evidence of the benefits of vitamin D3 within pregnant women and the effect, if any, on the numerous physiological processes taking place within both the mother and the foetus. We found data indicating that vitamin D3 can prove to be very important in preventingreeclampsia, gestational diabetes and congenital malformations of the foetus.
Conclusion: The administration of vitamin D3 may be a potential technique to prevent complications to the mother and the developing foetus both during and after pregnancy, either solely or as a combined therapy.

Keywords: Cholecalciferol, Osteoporosis, Deficiency, Supplement, Dosage,

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Please cite this article as: Lazarov N, Saghir F. How Does Vitamin D Supplementation Change the Outcome for Mother and Child? 2024 Jan-Mar;30(1):5410-5413. [Crossref - 10.5272/jimab.2024301.5410]

Corresponding AutorCorrespondence to: Nikolai Lazarov, Department of Obstetrics and Gynecology, Medical Faculty, Trakia University, Stara Zagora; 11, Armeyska Str., Stara Zagora, Bulgaria; E-mail: n.lazaroff@gmail.com

REFERENCES:
1. Hollis B. Vitamin D requirement during pregnancy and lactation, Journal Of Bone And Mineral Research, 2009 Dec; 22 (2), 39-44.
2. Wagner CL, Hollis BW. The Implications of Vitamin D Status During Pregnancy on Mother and her Developing Child. Front Endocrinol (Lausanne). 2018 Aug 31;9:500. [PubMed]
3. Barrett H, McElduff A. Vitamin D and pregnancy: An old problem revisited, Science Direct Journal, 2010 Aug; 24(4), 527-539.
4. Abrams S, Hawthorne K, Rogers SP, Hicks PD, Carpenter TO. Effects of ethnicity and vitamin D supplementation on vitamin D status and changes in bone mineral content in infants, Bio Med Open Access Journal, 2010 Jan; 12(6), 217-234.
5. Thiele D, Senti J, Anderson CM. Maternal vitamin D supplementation to meet the needs of the breastfed infant: A systematic review, 2013 May; Journal Of Human Lactation, 29(2), 163-170.
6. Roth DE, Gernand AD, Morris SK, Pezzack B, Islam MM, Dimitris MC, et al. Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial. Trials. 2015 Jul 14;16:300. [PubMed]
7. Uriu-Adams J, Obican S, Keen C. Vitamin D and maternal and child health: Overview and implications for dietary requirements, birth defects research part C: Embryo Today Reviews, 2013 Mar; 99(1), 24-44.
8. Bi WG, Nuyt AM, Weiler H, Leduc L, Santamaria C, Wei SQ. Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality: A Systematic Review and Meta-analysis. JAMA Pediatr. 2018 Jul 1;172(7):635-645. [PubMed]
9. Kaushal M, Magon N. Vitamin D in pregnancy: A metabolic outlook, Indian J Endocrinology Metabolism, 2013 Jan; 17(1), 76-82.
10. Floreskul V, Juma FZ, Daniel AB, Zamir I, Rawdin A, Stevenson M, et al. Cost-Effectiveness of Vitamin D Supplementation in Pregnant Woman and Young Children in Preventing Rickets: A Modeling Study. Front Public Health. 2020 Sep 4;8:439. [PubMed]
11. Wagner C, Hollis B, Kotsa K, Fakhoury H, Karras SN. Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications, Rev Endocrinology Metabolic Discord, 2017 Sep; 18(1), 307-322.
12. B.Hollis, D.Johnson, T.C.Hulsey, M.Ebeling, C.L.Wagner. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness, The American Society For Bone And Mineral Research, 2011 Oct; 26(10), 2341-2357.
13. Fiscaletti M, Stewart P, Munns CF. The importance of vitamin D in maternal and child health: a global perspective. Public Health Rev. 2017 Sep 1;38:19. [PubMed]

Received: 15 June 2023
Published online: 07 March 2024

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