head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2024, vol. 30, issue1
Subject Area: Medicine
DOI: 10.5272/jimab.2024301.5332
Published online: 30 January 2024

Case report
J of IMAB. 2024 Jan-Mar;30(1):5332-5335
Aleksander Popov1ORCID logoCorresponding Autoremail, Klimentina Gospodinova1ORCID logo, Milen Karaivanov2ORCID logo,
1) Department of Dermatology, Venereology and Allergology, Medical University - Pleven, Bulgaria.
2) Department of General and Clinical Pathology, Medical University - Pleven, Bulgaria.

We describe a 47-year-old healthy man who, after an injury to the third finger of the right hand, developed a reddened papule that did not disappear. Over a period of three months, edema developed on the finger and dorsum of the right hand, followed by several variegated nodules along the 3rd finger, dorsum of the right hand, and right forearm. There are no subjective complaints. The patient has an aquarium at home, and the complaints coincide with a period of growth of the fish in it. The diagnosis of Mycobacterium marinum infection is made on the basis of history, clinical picture, histology and molecular genetic testing for mycobacteria. Treatment with numerous antibacterial agents was carried out, and the long-term (9 months) therapy with clarithromycin, rifampicin and ethambutol, appointed after the diagnostic clarification, led to the cure of the infection. A brief review of the literature on the issue is made.

Keywords: atypical mycobacteria, mycobacterium marinum, granulomatous inflammation, aquarium,

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Please cite this article as: Popov A, Gospodinova K, Karaivanov M. Atypical Mycobacterial Infection. J of IMAB. 2024 Jan-Mar;30(1):5332-5335. [Crossref - 10.5272/jimab.2024301.5332]

Corresponding AutorCorrespondence to: Aleksander Krasimirov Popov, Department of Dermatology, venereology and allergology, Medical University – Pleven; 91, General Vladimir Vazov Str., Pleven-5800, Bulgaria; E-mail: ak_popov@yahoo.com

1. Aubry A, Mougari F, Reibel F, Cambau E. Mycobacterium marinum. Microbiol Spectr. 2017 Apr;5(2). [PubMed]
2. Johnston J, Izumi A. Cutaneous Mycobacterium marinum Infection (“swimming pool granuloma”). Clin Dermatol. 1987 Jul-Sep;5(3):68-75. [PubMed]
3. Hashish E, Merwad A, Elgaml S, Amer A, Kamal H, Elsadek A, et. al. Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review. Vet Q. 2018 Dec;38(1):35-46. [ PubMed ]
4. Assiri A, Euvrard S, Kanitakis J. Cutaneous Mycobacterium Marinum Infection (Fish Tank Granuloma) in a Renal Transplant Recipient: Case Report and Literature Review. Cureus. 2019 Oct 28;11(10):e6013. [PubMed]
5. Jaled MM, Pedrini CMF, González P, Förster FJ, Anaya JS, Stengel FM. [Mycobacterium marinum skin infections. Epidemiology, clinical features and treatment.] [in Spanish] Med Cutan Iber Lat Am. 2010; 38(2):70-75. [Internet]
6. Bonamonte D, De Vito D, Vestita M, Delvecchio S, Ranieri LD, Santantonio M, et al. Aquarium-borne Mycobacterium marinum skin infection. report of 15 cases and review of the literature. Eur J Dermatology. 2013 Jul-Aug;23(4):510–6. [PubMed]
7. Bachiyska E, Atanasova Y, Baykova A, Yordanova S, Todorova Y. First Etiologically Confirmed Cases of Mycobacterium Marinum Infection in Bulgaria. Folia Med (Plovdiv). 2020 Jun 30;62(2):398–402. [PubMed]
8. Oaku S, Nagata M, Miyamoto Y, Ishii N, Aozasa N. Two cases of Mycobacterium marinum infection on the upper limbs. J Dermatol. 2017 Oct;44(10):e270- e271. [PubMed]
9. McArdle A, Nolan M, Fleming C, Tuite H, Markham T, Kelly JL. Mycobacterium marinum hand infection. ANZ J Surg. 2016 Dec;86(12):1066-1067. [PubMed]
10. di Meo N, Stinco G, Trevisini S, De Marchi S, Albano A, Trevisan G. Sporotrichoid Mycobacterium marinum infection in an elderly woman. Dermatol Online J. 2015 May 18;21(5):13030/qt0sj418qp. [PubMed]
11. Canetti D, Riccardi N, Antonello R, Nozza S, Sotgiu G. Mycobacterium marinum: A brief update for clinical purposes. Eur J Intern Med. 2022 Nov;105:15-7. [PubMed]
12. Sia TY, Taimur S, Blau DiM, Lambe J, Ackelsberg J, Yacisin K, et al. Clinical and Pathological Evaluation of Mycobacterium marinum Group Skin Infections Associated with Fish Markets in New York City. Clin Infect Dis. 2016 Mar 1;62(5):590-5. [PubMed]
13. Rallis E, Koumantaki-Mathioudaki E. Treatment of Mycobacterium marinum cutaneous infections. Expert Opin Pharmacother. 2007 Dec;8(17):2965–78. [PubMed]
14. Bonnet E, Debat Zoguereh D, Petit N, Ravaux I, Gallais H. Clarithromycin: a potent agent against infections due to mycobacterium marinum. Clin Infect Dis. 1994 Apr;18(4):664-6. [PubMed]
15. Brans R, Rübben A, Poblete-Gutiérrez P. [Cutaneous infection with Mycobacterium marinum. successful therapy with rifampicin and clarithromycin.] [in German] Hautarzt. 2004 Jan;55(1):76–9. [PubMed]
16. Johnson RP, Xia Y, Cho S, Burroughs RF, Krivda SJ. Mycobacterium marinum infection: A case report and review of the literature. Cutis. 2007 Jan;79(1):33-6. [PubMed]
17. Rallis E, Koumantaki-mathioudaki E, Frangoulis E, Chatziolou E, Katsambas A. Severe sporotrichoid fish tank granuloma following infliximab therapy. Am J Clin Dermatol. 2007;8(6):385-8. [PubMed]
18. Tsiolakkis G, Liontos A, Filippas-Ntekouan S, Matzaras R, Theodorou E, Vardas M, et al. Mycobacterium marinum: A Case-Based Narrative Review of Diagnosis and Management. Microorganisms. 2023 Jul 13;11(7):1799. [PubMed]

Received: 12 October 2023
Published online: 30 January 2024

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