head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2023, vol. 29, issue4
Subject Area: Medicine
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DOI: 10.5272/jimab.2023294.5286
Published online: 15 December 2023

Review article
J of IMAB. 2023 Oct-Dec;29(4):5286-5290
IRREVERSIBLE ELECTROPORATION FOR CANCER TREATMENT: A REVIEW
Tihomir Georgiev1ORCID logoCorresponding Autoremail, Georgi Todorov2, 3ORCID logo,
1) Department of Medical Equipment, Electronic and Information Technologies, Medical University of Varna, Bulgaria.
2) E.S. Interventional radiology; Diagnostic imaging, radiotherapy and interventional radiology dept.; Faculty of Medicine, Medical University - Varna, Bulgaria.
3) Interventional radiology center, Imaging diagnostics clinic, “St. Marina” University Hospital – Varna, Medical University of Varna, Bulgaria.

ABSTRACT:
Introduction: Prostate, pancreatic and liver cancers are a major cause of death in Europe and including Bulgaria. Some methods for treatment include the use of electric current to create pores in the cells' membranes, and can be used in combination with other techniques, while an electric field with enough strength causes irreversible electroporation (IRE) and is a separate technique.
Material and methods:Search was conducted for scientific articles about electroporation and IRE.
Results: Most important parameters reported in scientific articles are electric field distribution, tissue characteristics and interaction, electric pulse settings. Articles that report patient outcomes suggest several possible advantages of – retaining urinary and sexual functions, possible increase of overall survival rate, low rate of serious adverse events and promising results when applied with chemotherapy. However, there are some studies that do not corroborate these results. The technique is also used for the treatment of renal cancer, and there are researches indicating a potential for use in ovarian, cervical and breast cancer.
Conclusion:
Studies suggest the IRE method is safe and feasible for the treatment of prostate cancer, pancreatic cancer and liver cancer, but improvements in the protocols is needed to prevent a decrease of quality of life.

Keywords: electroporation, irreversible electroporation, electroporation therapies,

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Please cite this article as: Georgiev T, Todorov G. Irreversible Electroporation for Cancer Treatment: A Review. J of IMAB. 2023 Oct-Dec;29(4):5286-5290.
[Crossref - 10.5272/jimab.2023294.5286]

Corresponding AutorCorrespondence to: Tihomir Georgiev, Department of Medical Equipment, Electronic and Information Technologies in Healthcare, Faculty of Public Health, Medical University of Varna; 55, Marin Drinov Str., Varna, Bulgaria; E-mail: tyssho@gmail.com

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Received: 14 March 2023
Published online: 19 December 2023

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