head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2023, vol. 29, issue4
Subject Area: Medicine
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DOI: 10.5272/jimab.2023294.5139
Published online: 02 October 2023

Original article
J of IMAB. 2023 Oct-Dec;29(4):5139-5144
SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY
Preslav Vasilev1ORCID logoCorresponding Autoremail, Savelina Popovska2ORCID logo, Milen Karaivanov2ORCID logo, Dobromir Dimitrov3ORCID logo, Ivelina Yordanova1ORCID logo,
1) Department of Dermatology, Venereology and Allergology, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.
2) Department of General and Clinical Pathology, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.
3) Surgical Oncology Department, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.

ABSTRACT:
Introduction: The incidence of Squamous cell carcinoma of the skin (SCCs) increases annually, and this process will likely be continued because of sun exposure, outdoor activities and the aging population.  
Objectives: The aim of our study is to analyse clinicohistopathological features, recurrence, metastasis and mortality rates of SCCs in Pleven, Lovech region, Bulgaria.
Methods: We investigated 355 patients with histologically confirmed SCCs for the period 2016 – 2022 and carried out a detailed histopathological analysis of 100 tumors. They were divided into two groups according to their macroscopic diameter: with low risk for recurrence and metastases (<20mm) and high – risk (>20mm). We studied the localisation, histological subtype, tumor cell differentiation, microscopic depth of invasion, perineural and lymphovascular invasion, stromal lymphocyte infiltration.
Results: We revealed that 73,3% of the patients with SCCs reported severe sunburns, and 1,13% of them underwent immunosuppressive treatment. Head and Neck localisation is the most common – 72,7%. We established a mean histological depth of SCCs of 5,92mm, lymphovascular invasion in 7% and perineural invasion in 5% of the cases. We found that tumors with a macroscopic diameter >20mm have a greater depth of invasion in comparison to SCCs with a smaller diameter. We found an incidence of local recurrence of 4,8%, lymph node metastases at 5,1%, far metastases in internal organs at 2,25% and mortality at 1,97%.
Conclusion: Clinicohistopathological features of SCCs with related to recurrence, metastasis and mortality are localisation on the scalp, ears or lips, tumor size >20mm, depth of invasion >6mm, poor tumor cell differentiation, perineural and lymphovascular invasion, low or absent stromal lymphocyte infiltration.

Keywords: histopathology, squamous cell carcinoma, skin cancer, recurrence, metastasis, mortality,

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Please cite this article as: Vasilev P, Popovska S, Karaivanov M, Dimitrov D, Yordanova I. Squamous cell carcinoma of the skin: a study of clinicohistopathological correlations predictive for recurrence, metastasis and mortality. J of IMAB. 2023 Oct-Dec;29(4):5139-5144. [Crossref - 10.5272/jimab.2023294.5139]

Corresponding AutorCorrespondence to: Preslav Plamenov Vasilev, Department of Dermatology and Venereology Faculty of Medicine, Medical University-Pleven; 91, General Vladimir Vazov str. 5800, Pleven, Bulgaria; E-mail: preslav.vasilev@abv.bg

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Received: 27 April 2023
Published online: 02 October 2023

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