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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2023, vol. 29, issue4
Subject Area: Medicine
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DOI: 10.5272/jimab.2023294.5139
Published online: 02 October 2023
Original article
J of IMAB. 2023 Oct-Dec;29(4):5139-5144
SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY
Preslav Vasilev1
, Savelina Popovska2, Milen Karaivanov2, Dobromir Dimitrov3, Ivelina Yordanova1,
1) Department of Dermatology, Venereology and Allergology, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.
2) Department of General and Clinical Pathology, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.
3) Surgical Oncology Department, University Hospital “Dr Georgi Stranski”, Faculty of Medicine, Medical University-Pleven, Bulgaria.
ABSTRACT:
Introduction: The incidence of Squamous cell carcinoma of the skin (SCCs) increases annually, and this process will likely be continued because of sun exposure, outdoor activities and the aging population.
Objectives: The aim of our study is to analyse clinicohistopathological features, recurrence, metastasis and mortality rates of SCCs in Pleven, Lovech region, Bulgaria.
Methods: We investigated 355 patients with histologically confirmed SCCs for the period 2016 – 2022 and carried out a detailed histopathological analysis of 100 tumors. They were divided into two groups according to their macroscopic diameter: with low risk for recurrence and metastases (<20mm) and high – risk (>20mm). We studied the localisation, histological subtype, tumor cell differentiation, microscopic depth of invasion, perineural and lymphovascular invasion, stromal lymphocyte infiltration.
Results: We revealed that 73,3% of the patients with SCCs reported severe sunburns, and 1,13% of them underwent immunosuppressive treatment. Head and Neck localisation is the most common – 72,7%. We established a mean histological depth of SCCs of 5,92mm, lymphovascular invasion in 7% and perineural invasion in 5% of the cases. We found that tumors with a macroscopic diameter >20mm have a greater depth of invasion in comparison to SCCs with a smaller diameter. We found an incidence of local recurrence of 4,8%, lymph node metastases at 5,1%, far metastases in internal organs at 2,25% and mortality at 1,97%.
Conclusion: Clinicohistopathological features of SCCs with related to recurrence, metastasis and mortality are localisation on the scalp, ears or lips, tumor size >20mm, depth of invasion >6mm, poor tumor cell differentiation, perineural and lymphovascular invasion, low or absent stromal lymphocyte infiltration.
Keywords: squamous cell carcinoma of the skin, histopathology, recurrence, metastasis, mortality,
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Please cite this article as: Vasilev P, Popovska S, Karaivanov M, Dimitrov D, Yordanova I. Squamous cell carcinoma of the skin: a study of clinicohistopathological correlations predictive for recurrence, metastasis and mortality. J of IMAB. 2023 Oct-Dec;29(4):5139-5144. [Crossref - 10.5272/jimab.2023294.5139]
Correspondence to: Preslav Plamenov Vasilev, Department of Dermatology and Venereology Faculty of Medicine, Medical University-Pleven; 91, General Vladimir Vazov str. 5800, Pleven, Bulgaria; E-mail: preslav.vasilev@abv.bg
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Received: 27 April 2023
Published online: 02 October 2023