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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2023, vol. 29, issue2
Subject Area: Medicine
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DOI: 10.5272/jimab.2023292.4928
Published online: 17 May 2023
Case report
J of IMAB. 2023 Apr-Jun;29(2):4928-4931
CLIPPERS SYNDROME – MRI FEATURES AND DIAGNOSTIC IMAGING FOLLOW-UP IN A PATIENT – CASE DISCUSSION AND REVIEW OF THE LITERATURE
Radoslav Georgiev
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Department of Radiology, University Hospital St. Marina, Medical University Varna, Bulgaria.
ABSTRACT:
Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) syndrome is a rare neurological disorder with uncertain etiology, pathogenesis and clinical course. Pittock et al. in 2010 first described this chronic inflammatory neurologic condition, which preferably affects the brainstem. There is an infiltration with inflammatory cells of the affected regions and typical dotted and curvilinear contrast-enhancement zones on magnetic resonance imaging (MRI), including leptomeninges. I present one case of a 41-year-old male with gradual onset of suspected infectious disease and neurological worsening with typical MRI features, with a biopsy confirmed diagnosis and follow-up for 15 months. The MRI findings and the evolution of the disease can narrow the differential-diagnostic spectrum in such a clinical case.
Keywords: CLIPPERS, brainstem, MRI,
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Please cite this article as: Georgiev R. CLIPPERS syndrome – MRI features and diagnostic imaging follow-up in a patient – case discussion and review of the literature. J of IMAB. 2023 Apr-Jun;29(2):4928-4931. DOI: 10.5272/jimab.2023292.4928
Correspondence to: Assoc. prof. Radoslav Georgiev, MD, PhD, Department of Radiology, University Hospital St. Marina; 1, Hristo Smirnenski Boul., 9010 Varna, Bulgaria; E-mail: drradogeorgiev@abv.bg
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Received: 06 February 2023
Published online: 17 May 2023