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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2022, vol. 28, issue3
Subject Area: Medicine
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DOI: 10.5272/jimab.2022283.4525
Published online: 29 August 2022
Original article
J of IMAB. 2022 Jul-Sep;28(3):4525-4531
EFFECTS OF DRUG BETAMETHASONE ON HEMATOLOGICAL PARAMETERS OF RATTUS NORVEGICUS (BERKENHOUT 1769) IN VIVO CONDITIONS
Edhem Hasković1,
, Safija Herenda2 
, Amina Herenda1,, Denis Hasković3,, Ena Hasković 4,, Amina Selimović5,,
1) Department of Biology, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
2) Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
3) Clinical Center, University of Sarajevo, Organizational unit clinical pathology, cytology and human genetics, Sarajevo, Bosnia and Herzegovina.
4) Clinical Center, University of Sarajevo, Organizational unit clinical biochemistry with immunology, Sarajevo, Bosnia and Herzegovina.
5) Clinical Center, University of Sarajevo, Pediatric Clinic, Sarajevo, Bosnia and Herzegovina.
ABSTRACT:
Glucocorticoids prevent or suppress the full inflammatory response to the infectious, immunological or physical agents by inhibiting early inflammatory events such as edema or cell exudation. The main effect of glucocorticoids on the inflammatory process is the inhibition or recruitment of neutrophils and monocytes. In this study, the effect of the glucocorticoid betamethasone on the hematological parameters of rats of the species Rattus norvegicus Berkenhout 1769 was examined in vivo. Betamethasone has been shown to affect the values of hematological parameters four hours after application and leads to a significant decrease in the prevalence of lymphocytes and monocytes, but also leads to a statistically significant increase in erythrocyte count, hemoglobin concentration and hematocrit values.
Keywords: Glucocorticoid, hematology, in vivo condition,
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Please cite this article as: Haskovic E, Herenda S, Herenda A, Haskovic D, Haskovic E, Selimovic A. Effects of drug betamethasone on hematological parameters of Rattus norvegicus (Berkenhout 1769) in vivo conditions. J of IMAB. 2022 Jul-Sep;28(3):4525-4531.
DOI: 10.5272/jimab.2022283.4525
Correspondence to: Dr Safija Herenda, Assoc. Prof., Department of Chemistry, Faculty of Science, University of Sarajevo; Zmaja od Bosne 33-35, Sarajevo, Bosnia and Herzegovina; E-mail: islamovic.safija@gmail.com
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Received: 22 November 2021
Published online: 29 August 2022