head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2022, vol. 28, issue1
Subject Area: Medicine
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DOI: 10.5272/jimab.2022281.4305
Published online: 25 March 2022

Original article
J of IMAB. 2022 Jan-Mar;28(1):4305-4309
DYNAMIC CHANGES OF TISSUE ENZYMES AND THE ITS INFLUENCE ON WOUND HEALING OF NASAL MUCOSA IN THE POSTOPERATIVE PERIOD
Marianna A. Zavalii1ORCID logo Corresponding Autoremail, Aleksey N. Orel1ORCID logo, Tatianna A. Krylova1ORCID logo, Denis M. Kedrovskiy1ORCID logo, Dilyana Vicheva2ORCID logo,
1) Department of Otorhinolaryngology, Medical Academy named after S.I. Georgievsky of Vernadsky CFU, Simferopol, Crimea.
2) Department of Otorhinolaryngology, Medical Faculty, Medical University of Plovdiv, Bulgaria.

ABSTRACT:
Intranasal surgery is widely spread all over the world and has the leading position among all otorhinolaryngological surgical interventions. However, any surgery makes sensitive trauma to the ciliaryepithelium that covers the nasal cavity and paranasal sinuses despite the modern technics of operations. That’s why reveling peculiarities, patterns and ways of correction of nasal mucosa regeneration in the postoperative period is very important for clinicians. So the main aim of our paper is to investigate the role of some tissue enzymes in the process of nasal mucosa regeneration after surgical interventions on the structures of the nasal cavity in adults.
As a result of our investigation, the role of some tissue enzymes was shown. We have based the usage of drugs that influence wound healing.
Thus, the proper medicines have positive effects on the regeneration processes of the ciliated epithelium. A more thorough investigation of the role of these enzymes will allow developing methods of its correction for improving the efficiency of endonasal surgery rapid and qualitative recovery of mucociliary clearance.

Keywords: ciliated epithelium, intranasal surgery, transforming growth factor-beta, matrix metalloproteinases,

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Please cite this article as: Zavalii MA, Orel AN, Krylova TA, Kedrovskiy DM, Vicheva D. Dynamic changes of tissue enzymes and the its influence on wound healing of nasal mucosa in the postoperative period. J of IMAB. 2022 Jan-Mar;28(1):4305-4309. DOI: 10.5272/jimab.2022281.4305

Corresponding AutorCorrespondence to: Marianna A. Zavalii MD, Department of Otorhinolaryngology, Medical Academy named after S.I. Georgievsky of Vernadsky Crimean Federal University, 295000, Crimea, Simferopol, bul. Lenina 5/7; 295051, Simferopol, bul. Lenina 5/7, Crimea; E-mail: mariannazavalii@gmail.com

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Received: 13 August 2021
Published online: 25 March 2022

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