head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2022, vol. 28, issue1
Subject Area: Medicine
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DOI: 10.5272/jimab.2022281.4284
Published online: 18 March 2022

Review article
J of IMAB. 2022 Jan-Mar;28(1):4284-4288
MODERN APPLICATIONS OF OZONE FOR COVID-19 DISINFECTION AND TREATMENT
Galina Yaneva1ORCID logo Corresponding Autoremail, Tsonka Dimitrova1ORCID logo, Dobri Ivanov1ORCID logo, Diana Ivanova2ORCID logo, Gergana Ingilizova3ORCID logo, Sergei Slavov4, 5ORCID logo,
1) Department of Biology, Faculty of Pharmacy, Medical University of Varna, Bulgaria.
2) Department of Biochemistry, Molecular Medicine and Nutrigenomics, Faculty of Pharmacy, Medical University, Varna, Bulgaria.
3) Vita” Multidisciplinary Hospital for Active Treatment – Sofia, Bulgaria.
4) University Hospital of Obstetrics and Gynecology “Maichin Dom”, Sofia, Bulgaria.
5) Department of Obstetrics and Gynecology, Medical University, Sofia, Bulgaria.

ABSTRACT:
Coronavirus disease 2019 represents a serious challenge for modern society worldwide because of the considerable and unfavourable consequences of the pandemic in terms of human health, economics and social life. In the present concise survey, some essential peculiarities of ozone as disinfecting and therapeutic means under the conditions of COVID-19 pandemic as reflected in the recent literature are described. Particularttention is paid to modern hospital disinfection means and methods. Ozone exerts antiviral activity through the inhibition of viral replication and direct inactivation of viruses by interfering with the virus replication phase and attacking capsid proteins. Ozone therapy is very inexpensive and may safely exploit the critical vulnerability in COVID-19.

Keywords: COVID-19 pandemic, ozone, ozone disinfection, ozone therapy,

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Please cite this article as: Yaneva G, Dimitrova T, Ivanov D, Ivanova D, Ingilizova G, Slavov S. Modern applications of ozone for COVID-19 disinfection and treatment. J of IMAB. 2022 Jan-Mar;28(1):4284-4288. DOI: 10.5272/jimab.2022281.4284

Corresponding AutorCorrespondence to: Galina Yaneva, BS, PhD, Department of Biology, Faculty of Pharmacy, Medical University of Varna; 84, Tsar Osvoboditel Blvd., Varna-9002, Bulgaria; E-mail: galina.yanevaa@gmail.com

REFERENCES:
1. Blanchard EL, Lawrence JD, Noble JA, Xu M, Joo T, Ng NL, et al. Enveloped virus inactivation on personal protective equipment by exposure to ozone. Version 2. medRxiv. 2020 May 26:2020.05.23.20111435.
2. Kumar GD, Williams RC, Sumner SS, Eifert JD. Effect of ozone and ultraviolet light on Listeria monocytogenes populations in fresh and spent chill brines. Food Control. 2016;59:172-177.
3. Pachejieff A, Kostov I. [Contamination in cord blood samples]. [in Bulgarian] Akush Ginekol. 2017;56(10):30-34.
4. ISCO3. Potential use of ozone in SARS-CoV-2/COVID-19. Madrid: International Scientific Committee of Ozone Therapy. 2020 March 14. [Internet]
5. Bayarri B, Cruz-Alcalde A, López-Vinent N, Micó MM, Sans C. Can ozone inactivate SARS-CoV-2? A review of mechanisms and performance on viruses. J Hazard Mater. 2021 Aug 5;415:125658. [PubMed]
6. The National Institute for Occupational Safety and Health (NIOSH). Ozone. CDC. June 22, 2019. [Internet]
7. Dennis R, Cashion A, Emanuel S, Hubbard D. Ozone gas: scientific justification and practical guidelines for improvised disinfection using consumer-grade ozone generators and plastic storage boxes. J Sci Med. 2020 Apr;2(1). [Crossref]
8. Wang J, Shen J, Ye D, Yan X, Zhang Y, Yang W, et al. Disinfection technology of hospital wastes and wastewater: Suggestions for disinfection strategy during coronavirus disease 2019 (COVID-19) pandemic in China. Environ Pollut. 2020 Jul;262:114665. [PubMed]
9. Arslan A, Topkaya E, Özbay B, Özbay I, Veli S. Application of O3/UV/H2O2 oxidation and process optimization for treatment of potato chips manufacturing wastewater. Water Environ J. 2017 Feb;31(1):64-71.  
10. Kleinbohl A, Willacy K, Friedson AJ, Chen P, Swain MR. Buildup of abiotic oxygen and ozone in moist atmospheres of temperate terrestrial exoplanets and its impact on the spectral fingerprint in transit observations. Astrophys J. 2018 Aug 1;862(2)1-12. [Crossref]
11. Gottschalk C, Libra JA, Saupe A. Ozonation of water and waste water: a practical guide to understanding ozone and its application. Hoboken NJ: John Wiley & Sons; 2008.
12. Wolf C, von Gunten U, Kohn T. Kinetics of inactivation of waterborne enteric viruses by ozone. Environ Sci Technol. 2018 Feb;52(4):2170-2177.
13. Hudson JB, Sharma M, Petric M. Inactivation of Norovirus by ozone gas in conditions relevant to healthcare. J Hosp Infect. 2007 May;66(1):40-45.
14. Hudson JB, Sharma M, Vimalanathan S. Development of a practical method for using ozone gas as a virus decontaminating agent. Ozone Sci Engin. 2009 May;31(3):216-223.
15. Singh S, Kumar V, Kapoor D, Dhanjal DS, Bhatia D, Jan S, et al. Detection and disinfection of COVID-19 virus in wastewater. Environ Chem Lett. 2021 Feb 22:1-17. [PubMed]
16. Rubio-Romero JC, Pardo-Ferreira MDC, Torrecilla-Garcнa JA, Calero-Castro S. Disposable masks: Disinfection and sterilization for reuse, and non-certified manufacturing, in the face of shortages during the COVID-19 pandemic. Saf Sci. 2020 Sep;129:104830. [PubMed]   
17. Dev Kumar G, Mishra A, Dunn L, Townsend A, Oguadinma IC, Bright KR, et al. Biocides and novel antimicrobial agents for the mitigation of coronaviruses. Front Microbiol. 2020 Jun 23;11:1351. [PubMed]  
18. Lepelletier D, Grandbastien B, Romano-Bertrand S, Aho S, Chidiac C, Géhanno JF, et al. What face mask for what use in the context of COVID-19 pandemic? The French guidelines. J Hosp Infect. 2020 Apr 26;105(3):414-8. [PubMed]  
19. Jerry J, O’Regan E, O’Sullivan L, Lynch M, Brady D. Do established infection prevention and control measures prevent spread of SARS-CoV-2 to the hospital environment beyond the patient room? J Hosp Infect. 2020 Aug;105(4):589-592. [PubMed]
20. Blanco A, Ojembarrena FB, Clavo B, Negro C. Ozone potential to fight against SAR-COV-2 pandemic: facts and research needs. Environ Sci Pollut Res Int. 2021 Apr;28(13):16517-16531.
21. Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020 Mar;367(6485):1444-1448.
22. Conti P, Gallenga CE, Tetи G, Caraffa A, Ronconi G, Younes A, et al. How to reduce the likelihood of coronavirus-19 (CoV-19 or SARS-CoV-2) infection and lung inflammation mediated by IL-1. J Biol Regul Homeost Agents. 2020 Mar-Apr;34(2):333-338.
23. Rowen RJ. Ozone therapy as a primary and sole treatment for acute bacterial infection: case report. Med Gas Res. 2018 Sep;8(3):121-124.
24. Cattel F, Giordano S, Bertiond C, Lupia T, Corcione S, Scaldaferri M, et al. Ozone therapy in COVID-19: A narrative review. Virus Res. 2021 Jan 2;291:198207. [PubMed]
25. Bocci V, Zanardia I, Valacchi G, Borrelli E, Travagli V. Validity of oxygen-ozone therapy as integrated medication form in chronic inflammatory diseases. Cardiovasc Hematol Disord Drug Targets. 2015;15(2):127-138.
26. Li LY, Ma RL, Du L, Wu AS. Ozonated autohemotherapy modulates the serum levels of inflammatory cytokines in gouty patients. Open Access Rheumatol. 2017 Aug;9:159-165.
27. Simonetti V, Quagliariello V, Franzini M, Iaffaioli RV, Maurea N, Valdenassi L. Ozone exerts cytoprotective and anti-inflammatory effects in cardiomyocytes and skin fibroblasts after incubation with doxorubicin. Evid Based Complement Alternat Med. 2019 Nov18;2019:2169103. [PubMed]
28. Zheng Z, Dong M, Hu K. A preliminary evaluation on the efficacy of ozone therapy in the treatment of COVID-19. J Med Virol. 2020 Nov;92(11):2348-2350.
29. Di Mauro R, Cantarella G, Bernardini R, Di Rosa M, Barbagallo I, Distefano A, et al. The biochemical and pharmacological properties of ozone: the smell of protection in acute and chronic diseases. Int J Mol Sci. 2019 Feb;20(3):634. [PubMed]
30. Valdenassi L, Franzini M, Ricevuti G, Rinaldi L, Galoforo AC, Tirelli U. Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19. Eur Rev Med Pharmacol Sci. 2020 Apr;24(8):4059-4061.
31. Geier MR, Geier DA. Respiratory conditions in coronavirus disease 2019 (COVID-19): Important considerations regarding novel treatment strategies to reduce mortality. Med Hypotheses. 2020 Jul;140:109760. [PubMed]
32. Marini S, Maggiorotti M, Dardes N, Bonetti M, Martinelli M, Re L, et al.; Italian Oxygen-Ozone Federation. Oxygen-ozone therapy as adjuvant in the current emergency in SARS-COV-2 infection: a clinical study. J Biol Regul Homeost Agents. 2020 May-Jun; 34(3):757-766.
33. Rowen RJ, Robins H. A plausible “penny” costing effective treatment for corona virus-ozone therapy. J Infect Dis Epidemiol. 2020;6(2):113. [Crossref
34. Martinez-Sanchez G, Schwartz A, Donna VD. Potential cytoprotective activity of ozone therapy in SARS-CoV-2/COVID-19. Antioxidants (Basel). 2020 May 6;9(5):389. [PubMed]
35. Hernández A, Papadakos PJ, Torres A, González DA, Vives M, Ferrando C, et al. Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19. Rev Esp Anestesiol Reanim. 2020 May;67(5):245-252.
36. Huiling H, Tong X. [A multicenter randomized controlled trial for ozone autohemotherapy in the treatment of novel coronavirus pneumonia (COVID-19).] [in Chinese] ChiCTR. 2020 Oct;(10). [Internet]
37. Soodmand M. A survey of the effect of ozonated water mouthwash on oral health and incidence of ventilator-associated pneumonia in patients connected to mechanical ventilation in intensive care units - a randomized clinical trial. IRCT. 20180213038720 N2,20.05.2020. [Internet]
38. Fernández-Cuadros ME, Albaladejo-Florín MJ, Álava-Rabasa S, Usandizaga-Elio I, Martinez-Quintanilla Jimenez D, Peña-Lora D, et al. Effect of rectal ozone (O3) in severe COVID-19 pneumonia: preliminary results. SN Compr Clin Med. 2020 Aug 3;1-9. [PubMed]
39. Fernández-Cuadros ME, Albaladejo-Florín MJ, Peña-Lora D, Álava-Rabasa S, Pérez-Moro OS. Ozone (O3) and SARS-CoV-2: physiological bases and their therapeutic possibilities according to COVID-19 evolutionary stage. SN Compr Clin Med. 2020 Jul 7;1-9. [PubMed]
40. Franzini M, Valdenassi L, Ricevuti G, Chirumbolo S, Depfenhart M, Bertossi D, et al. Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported. Int Immunopharmacol. 2020 Nov;88:106879. [PubMed].

Received: 21 June 2021
Published online: 18 March 2022

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