head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2021, vol. 27, issue4
Subject Area: Medicine
DOI: 10.5272/jimab.2021274.4010
Published online: 05 October 2021

Original article

J of IMAB. 2021 Oct-Dec;27(4):4010-4013
Sergei Slavov1, 2ORCID logo Corresponding Autoremail, Galina Yaneva3ORCID logo,
1) University Hospital of Obstetrics and Gynecology "Maichin Dom" Sofia, Bulgaria.
2) Department of Obstetrics and Gynecology, Medical University, Sofia, Bulgaria.
3) Department of Biology, Faculty of Pharmacy, Medical University, Varna, Bulgaria.

The aim of our study was to determine the effect of infertility and the method of fertilization on the frequency of preterm birth and low birth weight in singleton pregnancies achieved by in vitro fertilization (IVF).
The study was conducted in the period 01.2013 - 12.2017 and included 286 patients with births from singleton IVF pregnancies.  Classical IVF received 107 patients (group A1) and ICSI fertilization - 148 (group A2). Cases with tubal infertility were 81 (group B1), and 85 were with male infertility (group B2).
In group A1, birth prior to 37 weeks of gestation (w.g.) was found in 33 (30.8%) cases, compared to 26 (17.6%) in group A2 (p=0.029).In group A1, birth weight <2500 g was observed in 27 (25.3%) of cases, and in group A2 - in 17 (11.5%) of cases (p=0.015). In group B1, birth prior to 37 w.g. was established in 26 (32.1%) of the cases, compared to 9 (10.6%) in group B2 (p=0.003). In group B1 there was birth weight <2500 g in 19 (23.5%) of patients, compared to 6 (7.1%) in group B2 (p = 0.009). The average weight of the newborn and average duration of pregnancy was lower in groups with IVF fertilization and tubal infertility compared to ICSI fertilization and male infertility.
Tubal infertility and classical IVF fertilization are independent risk factors that increase the frequency of preterm birth and low birth weight in IVF singleton pregnancies.

Keywords: IVF, ICSI, preterm birth, low birth weight, tubal infertility, male infertility,

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Please cite this article as: Slavov S, Yaneva G. Preterm Birth and Low Birth Weight in Singleton Pregnancies after In vitro Fertilization- Influence of Infertility and Method of Fertilization. J of IMAB. 2021 Oct-Dec;27(4):4010-4013. DOI: 10.5272/jimab.2021274.4010

Corresponding AutorCorrespondence to: Sergei Svetoslavov Slavov, MD, PhD, University Hospital of Obstetrics and Gynecology "Maichin dom", Sofia; Department of Obstetrics and Gynecology, Medical University- Sofia; 15, Iv. Ev. Geshov Blvd., 1431 Sofia, Bulgaria; E-mail: sergeislavov66@gmail.com

1. Cavoretto P, Candiani M, Giorgione V, Inversetti A, Abu-Saba MM, Tiberio F, et al. Risk of spontaneous preterm birth in singleton pregnancies conceived after IVF/ICSI treatment: a meta-analysis of cohort studies. Ultrasound Obstet Gynecol. 2018 Jan;51(1):43-53. [PubMed]
2. Palomba S, Homburg R, Santagni S, La Sala GB, Orvieto R. Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review. Reprod Biol Endocrinol. 2016 Nov 4;14(1):76. [PubMed]
3. Qin J, Liu X, Sheng H, Wang H, Gao S.  Assisted reproductive technology and the risk of pregnancy-related complications and adverse pregnancy outcomes in singleton pregnancies: a meta-analysis of cohort studies. Fertil Steril. 2016 Jan;105(1):73-85.e1-6. [PubMed]
4. Chung K, Coutifaris C, Chalian R, Lin K, Ratcliffe SJ, Castelbaum AJ, et al. Factors influencing adverse perinatal outcomes in pregnancies achieved through use of in vitro fertilization. Fertil Steril. 2006 Dec;86(6):1634-41. [PubMed]
5. Ingilizova G, Kostov I, Kovachev E, Necheva V, Yaneva G. Survey of the influence of key factors on the number and percentage of preimplantation embryos obtained from patients with low ovarian reserve during IVF/ICSI procedure. MOJ Anat&Physiol. 2018 Jun;5(4):245-248. [Crossref]
6. Ingilizova G, Kovachev E, Ivanov D, Kostov I, Ivanov S. [Influence of stimulation protocol on maturity and morphological features of oocytes in patients with low ovarian reserve: study of 72 IVF/ICSI treatment cycles.] [in Bulgarian] Akush Ginekol (Sofiia). 2016; 55(3):10-3. [PubMed]
7. Ingilizova G, Kostov I, Lazarov I, Velkova D. Biological aspects of in vitro fertilization in patient with poor ovarian reserve. Varna Medical Forum. 2013; 2(2):23-26.
8. Seggers J, Pontesilli M, Ravelli ACJ, Painter RC, Hadders-Algra M, Heineman MJ, et al. Effects of in vitro fertilization and maternal characteristics on perinatal outcomes: a population-based study using siblings. Fertil Steril. 2016 Mar;105(3):590-598.e2. [PubMed]
9. Palomba S, Santagni S, Gibbins K, La Sala GB, Silver RM. Pregnancy complications in spontaneous and assisted conceptions of women with infertility and subfertility factors. A comprehensive review. Reprod Biomed Online. 2016 Nov;33(5):612-628. [PubMed]
10. Ingilizova G, Kostov I, Lazarov I, Velkova D. Intracytoplasmic ( sperm injection (ICSI) - advantages and disadvantages. Varna Medical Forum. 2013; 2(2):27-30.
11.  Palermo G, Joris H, Devroey P, Van Steirteghem AC. Pregnancies after intracytoplasmic sperm injection of a single spermatozoon into an oocyte. Lancet. 1992 Jul 4;340(8810):17-8. [PubMed]
12. Bonduelle M, Liebaers I, Deketelaere V, Derde M-P, Camus M, Devroey P, et al. Neonatal data on a cohort of 2889 infants born after ICSI (1991–1999) and of 2995 infants born after IVF (1983–1999). Human Reproduction. 2002 Mar;17(3):671–694. [Crossref ]
13. Hansen M, Kurinczuk JJ, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med. 2002 Mar 7;346(10):725-30. [PubMed]
14. Pinborg A, Wennerholm UB, Romundstad LB, Loft A, Aittomaki K, Söderström-Anttila V, et al. Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update. 2013 Mar-Apr;19(2):87-104. [PubMed]
15. Wang YA, Sullivan E, Black D, Dean J, Bryant J, Chapman M. Preterm birth and low birth weight after assisted reproductive technology-related pregnancy in Australia between 1996 and 2000. Fertil Steril. 2005 Jun;83(6):1650-8. [PubMed]
16. Nelson SM, Lawlor DA. Predicting live birth, preterm delivery, and low birth weight in infants born from in vitro fertilization: A prospective study of 144018 treatment cycles. PLOS Med. 2011 Jan 4; 8(1): e1000386. [PubMed]
17. Ombelet W, Cadron I, Gerris J, De Sutter P, Bosmans E, Martens G, et al. Obstetric and perinatal outcome of 1655 ICSI and 3974 IVF singleton and 1102 ICSI and 2901 IVF twin births: a comparative analysis. Reprod Biomed Online. 2005 Jul;11(1):76-85. [PubMed]
18. Ingilizova G, Ivanov D, Kovachev E, Evrev M, Kostov I, Necheva V. [Oocyte quality as a predictive marker for assessment of IVF/ICSI procedure outcome]. [in Bulgarian] Akush Ginekol (Sofiia). 2014; 53(6):41-6. [PubMed]
19. Kawwass JF, Crawford S, Kissin DM, Session DR, Boulet S, Jamieson DJ. Tubal factor infertility and perinatal risk after assisted reproductive technology. Obstet Gynecol. 2013 Jun;121(6):1263-1271. [PubMed]
20. Stuebe A, Genz M, Mcelrath T. Tubal factor infertility is associated with an increased risk of preterm birth compared with male factor infertility. AJOG. 2006 Dec 01;195(6 SMFM Abstracts S75) Abstract No.220. [Crossref]. .

Received: 22 May 2021
Published online: 05 October 2021

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