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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2021, vol. 27, issue3
Subject Area: Medicine
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DOI: 10.5272/jimab.2021273.3901
Published online: 20 August 2021
Case report
J of IMAB. 2021 Jul-Sep;27(3):3901-3904
ACUTE LIVER FAILURE ASSOCIATED WITH HEPATITIS E INFECTION IN A YOUNG MAN WITH IMMUNE THROMBOCYTOPENIA
Radka Komitova1, 2
, Аni Kevorkyan3, Еlitsa Golkocheva-Markova4, Мaria Atanasova5, Оliana Boykinova1, 2,
1) Department of Infectious Disease, Parasitology and Tropical Medicine, Faculty of Medicine, Medical University, Plovdiv, Bulgaria .
2) Department of Infectious Diseases, University Hospital St. George, Plovdiv, Bulgaria.
3) Department of Epidemiology and Disaster Medicine, Faculty of Public Health, Medical University, Plovdiv, Bulgaria.
4) National Reference Laboratory “Hepatitis viruses”, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
5) Virology Laboratory, Department of Microbiology and Immunology, Faculty of Pharmacy, Medical University, Plovdiv, Bulgaria.
ABSTRACT:
Autochthonous hepatitis E virus (HEV) infection is an increasingly recognized zoonosis in western countries. It is often asymptomatic but may cause severe illness, particularly in immunocompromised patients or those with underlying chronic liver diseases. Even less frequently, cases of acute failure have been reported. In this article, we describe a case of an immunocompetent patient who presented with symptomatic acute HEV hepatitis and progressed to acute liver failure. The patient was transferred to another hospital for further management and transplant consideration. Unfortunately, he developed multi-organ failure thereafter and died before the transplantation became feasible. Subsequently, HEV was confirmed in archived serum by detection of HEV RNA using commercial RT-PCR. The results of this study have confirmed that HEV testing should be included in the initial evaluation of every acute liver failure regardless of travel history, risk factors or underlying chronic liver diseases. This approach might support clinical decisions and enable to use of potential antiviral therapy.
Keywords: Hepatitis E virus, acute liver failure, ribavirin,
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Please cite this article as: Komitova R, Kevorkyan A, Golkocheva-Markova E, Atanasova M, Boykinova O. Acute liver failure associated with hepatitis E infection in a young man with immune thrombocytopenia. J of IMAB. 2021 Jul-Sep;27(3):3901-3904. DOI: 10.5272/jimab.2021273.3901
Correspondence to: Prof. Dr Radka Komitova, Department of Infectious Disease, Parasitology and Tropical Medicine, Faculty of Medicine, Medical University, Plovdiv; 15 A, Vassil Aprilov Blvd., 4000 Plovdiv, Bulgaria; E-mail: radka.komitova@yahoo.com
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Received: 19 January 2021
Published online: 20 August 2021