head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2021, vol. 27, issue3
Subject Area: Medicine
DOI: 10.5272/jimab.2021273.3863
Published online: 05 August 2021

Original article

J of IMAB. 2021 Jul-Sep;27(3):3863-3867
Tatyana Cvetkova1ORCID logo, Kalina Stoyanova1ORCID logo Corresponding Autoremail, Tsonko Paunov2ORCID logo, Stoyan Pavlov3ORCID logo,
1) Department of Infectious Diseases, Parasitology and Dermatovenereology, Faculty of Medicine, Medical University - Varna, Bulgaria.
2) Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University - Varna, Bulgaria.
3) Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University - Varna, Bulgaria.

Toxocariasis is a tissue zoonosis caused by Toxocara spp. and the exposure to these geohelminths varies in different parts of the population in a particular region.
The purpose of the study is to reveal the seroprevalence of toxocariasis in North-eastern Bulgaria and to establish its demographic structure.
Material/Methods: Within the scope of a broad seroepidemiological study, 701 individuals from North-eastern Bulgaria were tested for anti-Toxocara antibodies (ELISA) between 2017 and 2020. The results were stratified and analysed by age, gender, and place of residence.
Results: The overall seroprevalence of human toxocariasis in North-eastern Bulgaria is 18.54%. Children (18.85%) and adults (18.30%) show similar levels of infection, but the stratified analysis by age in 5-years intervals revealed notable discrepancies. In younger children, the seroprevalence is higher than the observed for the entire population (0-4 years - 22.22%; 5-9 years - 22.22%), while in adolescents and adults is lower than average. In the elderly, the seroprevalence rises to its highest levels (60-64 years - 30.56% and over 65 years -31.67%). Although there are variations between males and females, gender is not a significant factor for the distribution of toxocariasis. Higher seroprevalence levels in residents of the smaller settlements of the region (children - 28.18%; adults -29.10%) correspond to a 2.5-fold increase in the odds of contracting toxocariasis in comparison to the ones living in Varna city.
Conclusion: The overall seroprevalence of toxocariasis in North-eastern Bulgaria is alarmingly higher than the levels reported from other parts of the country, placing this unknown infection in a leading position among the parasitic zoonoses. The place of residence is the most significant factor driving the uneven distribution of the disease.

Keywords: Age Distribution, Demographics, Seroepidemiology, Sex Distribution, Toxocariasis, Residence Characteristics,

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Please cite this article as: Cvetkova T, Stoyanova K, Paunov T, Pavlov S. Demographic characteristics of the seroprevalence of human toxocariasis among the population of North-eastern Bulgaria. J of IMAB. 2021 Jul-Sep;27(3):3863-3867. DOI: 10.5272/jimab.2021273.3863

Corresponding AutorCorrespondence to: Kalina Stoyanova Pavlova, Department of Infectious Diseases, Parasitology and Dermatovenereology, Faculty of Medicine, Medical University – Varna; 55 Marin Drinov Str., 9000 Varna, Bulgaria; E-mail: drkalinasto@gmail.com

1. Rostami A, Ma G, Wang T, Koehler AV, Hofmann A, Chang BCH, et al. Human toxocariasis - A look at a neglected disease through an epidemiological ‘prism’. Infect Genet.2019 Oct;74:104002. [PubMed]
2. Macpherson CN. The epidemiology and public health importance of toxocariasis: a zoonosis of global importance. Int J Parasitol. 2013 Nov;43(12–13):999–1008. [PubMed]
3. Hotez PJ, Gurwith M. Europe’s neglected infections of poverty. Int J Infect Dis. 2011 Sep;15(9):611-9. [PubMed]
4. Rainova I, Kurdova R. A seroepidemiological survey of human toxocarosis in Bulgaria. In: Proceedings of the 11th International Congress of Parasitology. ICOPA 11. Medimond. 1 August 2006. pp.561-565.
5. Harizanov R, Rainova I, Kaftandjiev I. Human Cystic echinococcosis, Trichinellosis and Toxocariasis in Bulgaria: an update of data for 2015-2017. Int Med. 2019; 1(2):43-50. [Internet]
6. Eredzhebova M, Ilieva V, Martinova M, Cvetkova T, Stoyanova K. Seroprevalence of Toxocariasis in children and adults of Northeastern Bulgaria. Scr Sci Vox Stud. 2019;3(suppl. 1):20. [Internet]
7. R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna.  2018. [Internet]
8.Cvetkova T, Stoyanova K. [Toxocara seroprevalence among risk group for zoonotic distribution and healthy adults.] [in Bulgarian]  Varna Med Forum. 2017 Nov;6(Suppl 2):496-502. [Internet]
9. Rainova I, Kurdova R. Specifying clinical forms of toxocarosis after testing serologically suspected patients. ProblInfect Paras Dis. 2007;35(1):26–7. [Internet]
10. Rainova I. [Helminthozoonoses (trichinosis, toxocariasis, echinococcosis) in humans – epidemiological indicators, distribution, diagnostic and treatment.] Sofia: NICPD; 2020. 78 p. [In Bulgarian]
11. Rainova I, Harizanov R, Kaftandjiev I, Tsvetkova N, Mikov O, Kaneva E. Human Parasitic Diseases in Bulgaria in Between 2013-2014. Balk Med J. 2018 Jan 20;35(1):61-7. [PubMed]
12. Azam D, Ukpai O, Said A, Abd-Allah G, Morgan E. Temperature and the development and survival of infective Toxocara canis larvae. Parasitol Res. 2012 Feb;110(2):649–56. [PubMed]
13. Uzunova K, Nikolova N. [Etiological aspects of the stray dog’s population in Bulgaria.] [in Bulgarian] Vet Assem. 2017; 1-2:41-4. [Internet]
14. Cvetkova T, Stoyanova K, Paunov T. Contamination with Toxocara spp. eggs of environmental samples of public places of Varna city, Bulgaria. J of IMAB. 2018 Jul-Sep;24(3):2177-80. [Crossref]
15. Cvetkova T, Stoyanova K, Paunov T, Kaleva V. [Recidive of toxocariasis in child with geophagia.] [in Bulgarian] Sci InfectologyParasitol.2018; 1:45-7. [Internet]
16. Jones JL, Dargelas V, Roberts J, Press C, Remington JS, Montoya JG. Risk factors for Toxoplasma gondii infection in the United States. Clin Infect Dis. 2009 Sep 15;49(6):878-84. [PubMed].

Received: 21 October 2020
Published online: 05 August 2021

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