head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2021, vol. 27, issue3
Subject Area: Medicine
DOI: 10.5272/jimab.2021273.3829
Published online: 01 July 2021

Original article

J of IMAB. 2021 Jul-Sep;27(3):3829-3834
Konstantin Georgiev1ORCID logo Corresponding Autoremail, Yana Pacholova2ORCID logo,
1) LOR Department; MBAT Varna; Military Medical Academy, Bulgaria.
2) Family Centre Pan, Psychological and Speech Therapy Practice, Varna, Bulgaria.

Purpose: To explain the clinical findings of patients with profound unilateral deafness who have recovered the hearing function after a combined treatment of hyperbaric oxygenation and dehydrant therapy.
Material and method: 11 patients with profound sudden unilateral hearing loss above 90 dB SPL, intolerance to sounds similar to recruitment, at levels 10-20 dB above the hearing threshold (105-120 dB SPL), positive glycerol test and unexpected good recovery of hearing within 1-2 months are described.
Results: All patients have perfect outcome results without the use of glucocorticoids.
Conclusions: Based on articles about experiments with genetically modified animals and acquired deafness, we propose a possible mechanism of damage explaining the clinical findings and the favorable outcome of the disease – a disconnection between the tectorial membrane and stereocilia. Thus mechano-electrical transducer (MET) of hair cells cannot be activated. The combined use of hyperbaric oxygenation and dehydrant medications can lead to recovery of the hearing function.

Keywords: Unilateral Sensorineural Hearing Loss, Tectorial Membrane, Hair Cells,

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Please cite this article as: Georgiev K, Pacholova Y. Unilateral profound deafness – a possible mechanism. J of IMAB. 2021 Jul-Sep;27(3):3829-3834. DOI: 10.5272/jimab.2021273.3829

Corresponding AutorCorrespondence to: Konstantin Georgiev, LOR Department, Multiprofile Base for Active Treatment - Varna, Military Medical Academy; 3, Hristo Smirnenski Str., 9000 Varna, Bulgaria; E-mail: drkgeorgiev@abv.bg

1. Fettiplace R. Defining features of the hair cell mechanoelectrical transducer channel. Pflugers Arch. 2009 Oct;458(6):1115-23. [PubMed]
2. Georgiev K, Vazharov Iv, Bozov Cr, Kutsarov P, Stavrev D. "Sensorineural" Hearing Loss Due to Injuries of Cilio-Tectorial Juncion. 56th Science Conference of Russe University. 2017. p.156-163.  [Internet]
3. Legan PK, Lukashkina VA, Goodyear RJ, Lukashkin AN, Verhoeven K, Van Camp G, et al. A deafness mutation isolates a second role for the tectorial membrane in hearing. Nat Neurosci. 2005 Aug;8(8):1035-42. [PubMed]
4. Legan PK, Lukashkina VA, Goodyear RJ, Kossi M, Russell IJ, Richardson GP. A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. Neuron. 2000 Oct;28(1):273-85. [PubMed]
5. Taylor R, Bullen A, Johnson SL, Grimm-Gunter EM, Rivero F, Marcotti W, et al. Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice. Hum Mol Genet. 2015 Jan 1;24(1):37-49. [PubMed]
6. Jones GP, Elliott SJ, Russell IJ, Lukashkin AN. Modified protein expression in the tectorial membrane of the cochlea reveals roles for the striated sheet matrix. Biophys J. 2015 Jan 6;108(1):203-10. [PubMed]
7. Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, et al. Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. J Neurosci. 2011 Aug 24;31(34):12241-50. [PubMed]
8. Uziel A. Periods of sensitivity to thyroid hormone during the development of the organ of Corti. Acta Otolaryngol Suppl. 1986; 429:23-7. [PubMed]
9. Forrest D, Erway LC, Ng L, Altschuler R, Curran T. Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet. 1996 Jul;13(3):354-7. [PubMed]
10. Griffith AJ, Szymko YM, Kaneshige M, Quinonez RE, Kaneshige K, Heintz KA, et al. Knock-in mouse model for resistance to thyroid hormone (RTH): an RTH mutation in the thyroid hormone receptor beta gene disrupts cochlear morphogenesis. J Assoc Res Otolaryngol. 2002 Sep;3(3):279-88. [PubMed]
11. Winter H, Ruttiger L, Muller M, Kuhn S, Brandt N, Zimmermann U, et al. Deafness in TRbeta mutants is caused by malformation of the tectorial membrane. J Neurosci. 2009 Feb 25;29(8):2581-7. [PubMed]
12. Solares CA, Edling AE, Johnson JM, Baek MJ, Hirose K, Hughes GB, et al. Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides. J Clin Invest. 2004 Apr;113(8):1210-7. [PubMed]
13. Canlon B. The effect of acoustic trauma on the tectorial membrane, stereocilia, and hearing sensitivity: possible mechanisms underlying damage, recovery, and protection. Scand Audiol Suppl. 1988; 27:1-45. [PubMed]
14. Flock A, Flock B, Fridberger A, Scarfone E, Ulfendahl M. Supporting cells contribute to control of hearing sensitivity. J Neurosci. 1999 Jun 1;19(11):4498-507. [PubMed]
15. Cotanche DA. Regeneration of the tectorial membrane in the chick cochlea following severe acoustic trauma. Hear Res. 1987; 30(2-3):197-206. [PubMed]
16. Song Y, Xia A, Lee HY, Wang R, Ricci AJ, Oghalai JS. Activity-dependent regulation of prestin expression in mouse outer hair cells. J Neurophysiol. 2015 Jun 1;113(10):3531-42. [PubMed]
17. Mattox DE, Simmons FB. Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol. 1977 Jul-Aug;86(4 Pt 1):463-80. [PubMed]

Received: 17 October 2020
Published online: 01 July 2021

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