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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2021, vol. 27, issue2
Subject Area: Medicine
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DOI: 10.5272/jimab.2021272.3793
Published online: 08 June 2021
Review article
J of IMAB. 2021 Apr-Jun;27(2):3793-3798
CIRCULAR RNA – miRNA MEDIATED INTERACTION IN MYOCARDIAL INFARCTION
Yordanka Doneva1,2
, Veselin Valkov1,4, Yavor Kashlov1,2, Galya Mihaylova3, Atanas Angelov2,4, Maria Radanova3,
1) Department of Propedeutics of Internal Medicine, Medical University of Varna, Bulgaria.
2) Department of Internal Medicine, UMHAT “St. Marina”, Varna, Bulgaria.
3) Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, Bulgaria.
4) First Clinic of Cardiology, UMHAT St. Marina, Varna, Bulgaria.
ABSTRACT:
Circular RNA (circRNAs) belong to the long non-coding RNA family, but unlike the linear RNA in circular RNA, the 3’ and 5’ end in the RNA molecule are joined together, forming their circular structure. Until recently, circRNAs have been believed to be a side product of splicing, but now it is known that they have a wide range of biological functions, from regulators of gene expression to regulators of other non-coding RNAs - microRNAs (miRNAs). CircRNAs have the potential of being therapeutic targets and biomarkers for diseases. There are little data and only several investigations about this type of RNAs in myocardial infarction in humans.
This review summarizes the role of some new circRNA – miRNA interactions in the development of Myocardial Infarction.
Keywords: CircRNAs, miRNAs, myocardial infarction,
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Please cite this article as: Doneva Y, Valkov V, Kashlov Y, Mihaylova G, Angelov A, Radanova M. Circular RNA – miRNA mediated interaction in Myocardial Infarction. J of IMAB. 2021 Apr-Jun;27(1):3793-3798. DOI: 10.5272/jimab.2021272.3793
Correspondence to: Yordanka Doneva, UMBAL ”St. Marina”-Varna; 1, Hristo Smirnenski Blvd., Varna, Bulgaria; E-mail: d12_doneva@abv.bg
REFERENCES:
1. Diamantopoulos MA, Tsiakanikas P, Scorilas A. Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer.Ann Transl Med. 2018 Jun;6(12):241. [PubMed]
2. Wang W, Wang Y, Piao H, Li B, Huang M, Zhu Z, et al. Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease. PeerJ. 2019 May 8;7:e6831. [PubMed]
3. Chen LL, Yang L. Regulation of circRNA biogenesis. RNA Biol. 2015; 12(4):381-8. [PubMed]
4. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013 Mar 21;495(7441):333-8. [PubMed]
5. Petkovic S, Muller S. RNA circularization strategies in vivo and in vitro. Nucl Acids Res. 2015 Feb 27;43(4): 2454-65. [PubMed]
6. Memczak S, Papavasileiou P, Peters O, Rajewsky N. Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood. PloS One. 2015 Oct 20;10(10):e0141214. [PubMed]
7. Wang K, Long B, Liu F, Wang JX , Liu CY, Zhao B, et al. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Eur Heart J. 2016 Sep 1;37(33):2602-11. [PubMed]
8. Floris G, Zhang L, Follesa P, Sun T. Regulatory Role of Circular RNAs and Neurological Disorders. Mol Neurobiol. 2017 Sep;54(7):5156-65. [PubMed]
9. Li TR, Jia YJ, Wang Q, Shao XQ, Lv RJ. Circular RNA: a new star in neurological diseases. Int J Neurosci. 2017 Aug;127(8):726-34. [PubMed]
10. Zhang HD, Jiang LH, Sun DW, Hou JC, Ji ZL. CircRNA: a novel type of biomarker for cancer. Breast Cancer. 2018 Jan;25(1):1-7. [PubMed]
11. Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV , Berry K, Naldini MM ,et al.Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations. Cell. 2016 Apr 7;165(2):289-302 [PubMed]
12. Devaux Y, Creemers EE, Boon RA,Werfel S,Thum T, Engelhardt S, et al. Circular RNAs in heart failure. Eur J Heart Fail. 2017 Jun;19(6):701-9. [PubMed]
13. Vicens Q, Westhof E. Biogenesis of Circular RNAs. Cell. 2014 Sep 25;159(1):13-4. [PubMed]
14. Mumtaz PT, Taban Q, Dar MA, Mir S, Haq Z, Zargar SM, et al. Deep Insights in Circular RNAs: from biogenesis to therapeutics. Biol Proced Online. 2020 May 15;22:10. [PubMed]
15. Geng X, Jia Y, Zhang Y, Shi L, Li Q, Zang A, et al. Circular RNA: biogenesis, degradation, functions and potential roles in mediating resistance to anticarcinogens. Epigenomics. 2020 Feb;12(3):267-83. [PubMed]
16. Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, et al. Corrigendum: Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 2017 Feb 6;24(2):194. [PubMed]
17. Liu KS, Pan F, Mao XD, Liu C, Chen YJ. Biological functions of circular RNAs and their roles in occurrence of reproduction and gynecological diseases. Am J Transl Res. 2019 Jan 15;11(1):1-15. [PubMed]
18. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE,Liu J, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 2013 Feb;19(2):141-57. [PubMed]
19. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandieret O, et al. Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Mol Cell. 2017 Apr 6;66(1):22-37 e9. [PubMed]
20. Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, et al. A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Oncogene. 2018 Mar;37(13):1805-14. [PubMed]
21. Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, et al. Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis. J Natl Cancer Inst. 2018 Mar 1;110(3):304-15. [PubMed]
22. Dragomir M, Calin GA. Circular RNAs in Cancer - Lessons Learned From microRNAs. Front Oncol. 2018 May 28;8:179. [PubMed]
23. Cai Y, Yu X, Hu S, Yu J. A brief review on the mechanisms of miRNA regulation. Genomics Proteomics Bioinformatics. 2009 Dec;7(4):147-54. [PubMed]
24. Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013 Mar 21;495(7441):384-8. [PubMed]
25. Zhao X, Cai Y, Xu J. Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers.Int J Mol Sci. 2019 Aug 13;20(16):3926. [PubMed]
26. Militello G, Weirick T, John D, Doring C, Dimmeler S, Uchida S. Screening and validation of lncRNAs and circRNAs as miRNA sponges. Brief Bioinform. 2017 Sep 1;18(5):780-8. [PubMed]
27. Zhang Z, Yang T, Xiao J. Circular RNAs: Promising Biomarkers for Human Diseases. EBioMedicine. 2018 Aug;34:267-74. [PubMed]
28. Vausort M, Salgado-Somoza A, Zhang L, Leszek P, Scholz M, Teren A, et al. Myocardial Infarction-Associated Circular RNA Predicting Left Ventricular Dysfunction. J Am Coll Cardiol. 2016 Sep 13;68(11):1247-8. [PubMed]
29. Salgado-Somoza A, Zhang L, Vausort M, Devaux Y. The circular RNA MICRA for risk stratification after myocardial infarction. Int J Cardiol Heart Vasc. 2017 Nov 10;17:33-6. [PubMed]
30. Santer L, Bar C, Thum T. Circular RNAs: A Novel Class of Functional RNA Molecules with a Therapeutic Perspective. Mol Ther. 2019 Aug 7;27(8):1350-63. [PubMed]
31. Devaux Y, Vausort M, McCann GP, Zangrando J, Kelly D, Razvi N, et al. MicroRNA-150: a novel marker of left ventricular remodeling after acute myocardial infarction. Circ Cardiovasc Genet. 2013 Jun;6(3):290-8. [PubMed]
32. Wang K, Gan TY, Li N, Liu CY, Zhou LY, Gao JN,et al. Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression. Cell Death Differ. 2017 Jun;24(6):1111-20. [PubMed]
33. Siede D, Rapti K, Gorska AA, Katus HA, Altmuller J, Boeckel JN, et al. Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. J Mol Cell Cardiol. 2017 Aug;109:48-56. [PubMed]
34. Ren S, Lin P, Wang J, Yu H, Lv T, Sun L, et al. Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases via Functioning as an miRNA Sponge. Mol Ther Methods Clin Dev. 2020 Jun 6;18:215-29. [PubMed]
35. Li M, Ding W, Tariq MA, Chang W, Zhang X, Xu W, et al. A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p. Theranostics. 2018 Nov 12;8(21):5855-69. [PubMed]
36. Geng HH, Li R, Su YM, Xiao J, Pan M, Cai XX, et al. The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression. PloS One. 2016 Mar 21;11(3): e0151753. [PubMed]
37. Zhao YJ, Wang JH, Fu B,Ma MX, Li BX, Huang Q, et al. Effects of 3-aminobenzamide on expressions of poly (ADP ribose) polymerase and apoptosis inducing factor in cardiomyocytes of rats with acute myocardial infarction. Chin Med J (Engl). 2009 Jun 5;122(11):1322-7. [PubMed]
38. Cai L, Qi B, Wu X, Peng S, Zhou G, Wei Y, et al. Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b. J Mol Cell Cardiol. 2019 May;130:10-22. [PubMed]
39. Zhu Y, Pan W, Yang T, Meng X, Jiang Z,Taoet L, et al. Upregulation of Circular RNA CircNFIB Attenuates Cardiac Fibrosis by Sponging miR-433. Front Genet. 2019 Jun 20;10:564. [PubMed]
40. Tao L, Bei Y, Chen P, Lei Z, Fu S, Zhang H, et al. Crucial Role of miR-433 in Regulating Cardiac Fibrosis. Theranostics. 2016 Sep 10;6(12):2068-83. [PubMed]
41. Zhao B, Li G, Peng J, Ren L, Lei L, Ye H, et al. CircMACF1 Attenuates Acute Myocardial Infarction Through miR-500b-5p-EMP1 Axis.J Cardiovasc Transl Res. 2021 Feb;14(1):161-172. [PubMed]
42. Ahmat Amin MKB, Shimizu A, Ogita H. The Pivotal Roles of the Epithelial Membrane Protein Family in Cancer Invasiveness and Metastasis. Cancers (Basel). 2019 Oct 23;11(11):1620. [PubMed]
43. Li H, Zhang X, Jiang X, Ji X. The expression and function of epithelial membrane protein 1 in laryngeal carcinoma. Int J Oncol. 2017 Jan;50(1):141-8. [PubMed]
44. Sun GG, Wang YD, Cui DW, Cheng YJ, Hu WN. Epithelial membrane protein 1 negatively regulates cell growth and metastasis in colorectal carcinoma. World J Gastroenterol. 2014 Apr 14;20(14):4001-10. [PubMed]
45. Sun LY, Zhao JC, Ge XM, Zhang H, Wang CM, Bie ZD. Circ_LAS1L regulates cardiac fibroblast activation, growth, and migration through miR-125b/SFRP5 pathway. Cell Biochem. Funct. 2020 Jun;38(4):443-50. [PubMed]
46. Wang Y, Ma W, Lu S, Yan LH, Hu F, Wang ZH, et al. Androgen receptor regulates cardiac fibrosis in mice with experimental autoimmune myocarditis by increasing microRNA-125b expression. Biochem Biophys Res Commun. 2018 Nov 17;506(1):130-6. [PubMed]
47. You K, Li SY, Gong J, Fang JH, Zhang C, Zhang M, et al. MicroRNA-125b Promotes Hepatic Stellate Cell Activation and Liver Fibrosis by Activating RhoA Signaling. Mol Ther Nucleic Acids. 2018 Sep 7;12:57-66. [PubMed]
48. Wang X, Ha T, Zou J, Ren D, Liu L, Zhang X, et al. MicroRNA-125b protects against myocardial ischaemia/reperfusion injury via targeting p53-mediated apoptotic signalling and TRAF6. Cardiovasc Res. 2014 Jun 1;102(3):385-95. [PubMed].
Received: 16 December 2020
Published online: 08 June 2021