 |
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2021, vol. 27, issue1
Subject Area: Medicine
-
DOI: 10.5272/jimab.2021271.3564
Published online: 28 January 2021
Case report
J of IMAB. 2021 Jan-Mar;27(1):3564-3567
THYROID METASTASIS OF A SQUAMOUS CELL CARCINOMA OF THE TONGUE - A RARE CASE REPORT
Gergana Tosheva1
, Mira Siderova1, Elitsa Encheva2, Doroteya Malinova3,
1) Endocrinology Department, Faculty of Medicine, Clinic of Endocrinology and Metabolic Diseases, University Hospital St. Marina, Medical University - Varna, Bulgaria.
2) Radiotherapy Department, Faculty of Medicine, Clinic of Diagnostics Imaging and Radiotherapy, University Hospital St. Marina, Medical University - Varna, Bulgaria.
3) Department of General and Clinical Pathology, Faculty of Medicine, Clinic of General and Clinical Pathology, Forensic Medicine and Deontology, University Hospital St. Marina, Medical University - Varna, Bulgaria.
ABSTRACT:
Introduction: We present a patient with carcinoma of the tongue with а lymph node and thyroid metastasеs. The squamous cell cancer of the tongue’s 5-year survival rate has not been improved in the last three decades. Most common sites of metastases are the locoregional lymph nodes, followed by distant pulmonary, liver, bone and skin metastasеs. Only ten cases of metastases to the thyroid gland are reported in the literature.
Case report: A 79-year old man presented to the University Hospital in Varna, Bulgaria. Two months before admission, he noticed swelling of the tongue and progressive weight loss. The inspection of the oral cavity revealed a lesion on the left margin of the tongue. A biopsy was performed with a histological result of differentiated squamous cell carcinoma of the tongue. A computed tomography scan of the head and neck region discovered a lesion in the right thyroid lobe. 18-fluoro-2-deoxy-glucose-positron emission tomography imaging showed a metabolically active tumor of the tongue with hypermetabolic metastatic cervical lymph nodes and a zone with abnormally elevated fixation of 18F-FDG in the central part of the soft palate. The described thyroid nodule did not have an increased tracer uptake. It was cytologically assessed after fine-needle aspiration biopsy (FNAB) as a metastasis from squamous cell carcinoma of the tongue.
Conclusions: Distant metastases from tongue cancer to the thyroid gland are extremely rare and mostly occur in the advanced stages of malignancy.
Keywords: tongue, matastasis, thyroid gland,
- Download FULL TEXT /PDF 1258 KB/
Please cite this article as: Tosheva G, Siderova M, Encheva E, Malinova D. Thyroid metastasis of a squamous cell carcinoma of the tongue - a rare case report. J of IMAB. 2021 Jan-Mar;27(1):3564-3567. DOI: 10.5272/jimab.2021271.3564
Correspondence to: Gergana Tosheva Marinova, MD, Clinic of Endocrinology, University Hospital “St. Marina” Varna; 1, Hr. Smirnenski Blvd., 9010 Varna, Bulgaria; E-mail: gergana_tosheva@abv.bg
REFERENCES:
1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108. [PubMed]
2. Credé A, Locher M, Bredell M. Tongue cancer in young patients: case report of a 26-year-old patient. Head Neck Oncol. 2012 May;4(1):20. [PubMed]
3. Amar A, Rapoport A, Curioni OA, Dedivitis RA, Cernea CR, Brandão LG. Prognostic value of regional metastasis in squamous cell carcinoma of the tongue and floor of mouth. Braz J Otorhinolaryngol. 2013 Nov-Dec;79(6):734-7. [PubMed]
4. Dhull AK, Atri R, Dhankhar R, Chauhan AK, Kaushal V. Major Risk Factors in Head and Neck Cancer: A Retrospective Analysis of 12-Year Experiences. World J Oncol. 2018 Jun;9(3):80-84. [PubMed]
5. Báez A. Genetic and environmental factors in head and neck cancer genesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Apr-Jun;26(2):174-200. [PubMed]
6. Osaki T, Yoneda K, Yamamoto T, Kimura T, Matuoka H, Sakai H, et al. Clinical investigation on pulmonary metastasis of head and neck carcinomas. Oncology. 2000 Sep;59(3):196-203. [PubMed]
7. Probert JC, Thompson RW, Bagshaw MA. Patterns of Spread of Distant Metastasis in Head and Neck Cancer. Cancer. 1974 Jan;33(1):127-133. [PubMed]
8. Thomas M, Bhatt V, James G, Ayshford C. Metastasis to the thyroid from oral squamous cell carcinoma. Br J Oral Maxillofac Surg. 2009 Sep;47(6):500-1. [PubMed]
9. Mandai T, Ishida K, Ito S, Deguchi H, Hata T, Irei I, et al. A case of spindle cell carcinoma of the tongue metastasized to the thyroid gland. Asian J Oral Maxillofac Surg. 2011 Nov;23(4):181-185. [Crossref]
10. Hegerova L, Griebeler ML, Reynolds JP, Henry MR, Gharib H. Metastasis to the thyroid gland: report of a large series from the Mayo Clinic. Am J Clin Oncol. 2015 Aug;38(4):338-42. [PubMed]
11. Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F, et al. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin. 2017;67(1):51–64. [PubMed]
12. Attar E, Dey S, Hablas A, Seifeldin IA, Ramadan M, Rozek LS, et al. Head and neck cancer in a developing country: a population-based perspective across 8 years. Oral Oncol. 2010 Aug;46(8):591-6. [PubMed]
13. Ng JH, Iyer NG, Tan MH, Edgren G. Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study. Head Neck. 2017 Feb;39(2):297-304. [PubMed]
14. McDowell L, Collins M, Kleid S, Rischin D, Corry J. T4 squamous cell carcinoma of the tongue without mandibular involvement: surgery or chemoradiotherapy? Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Feb;117(2):163-9. [PubMed]
15. Stenson KM, Kunnavakkam R, Cohen EE, Portugal LD, Blair E, Haraf DJ, et al. Chemoradiation for patients with advanced oral cavity cancer. Laryngoscope. 2010 Jan;120(1):93–99. [PubMed]
16. Jones AS, Rafferty M, Fenton JE, Jones TM, Husband DJ. Treatment of squamous cell carcinoma of the tongue base: irradiation, surgery, or palliation? Ann Otol Rhinol Laryngol. 2007 Feb;116(2):92-9. [PubMed]
17. Huang Y, Wu LL, Xiang RL, Yu GY. Efficacy and Safety of Intro-Arterial Chemotherapy Combined with Radiotherapy on Head and Neck Cancer: A Systematic Review and Meta-Analysis. J Cancer 2019; 10(25):6233-6243. [PubMed]
18. Homma A, Onimaru R, Matsuura K, Thomas Robbins KT, Fujii M. Intra-arterial chemoradiotherapy for head and neck cancer. Jpn J Clin Oncol. 2016 Jan;46(1):4-12. [PubMed]
19. Kobayashi W, Kukobota K, Ito R, Sakaki H, Nakagawa H, Teh BG. Can Superselective Intra-Arterial Chemoradiotherapy Replace Surgery Followed by Radiation for Advanced Cancer of the Tongue and Floor of the Mouth? J Oral Maxillofac Surg. 2016 Jun;74(6):1248-54. [PubMed]
20. Mitsudo K, Hayashi Y, Minamiyama S, Ohashi N, Iida M, Iwai T, et al. Chemoradiotherapy using retrograde superselective intra-arterial infusion for tongue cancer: Analysis of therapeutic results in 118 cases. Oral Oncol. 2018 Apr;79:71-77. [PubMed].
Received: 02 January 2020
Published online: 28 January 2021