head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2019, vol. 25, issue2
Subject Area: Medicine
DOI: 10.5272/jimab.2019252.2589
Published online: 27 June 2019

Original article

J of IMAB. 2019 Apr-Jun;25(2):2589-2594
Shahm B. Mohammed1ORCID logo, Taras V. Upyr2ORCID logo, Olga M. Shapoval3ORCID logo, Larysa V. Lenchyk1ORCID logo Corresponding Autoremail, Kaloyan Georgiev4ORCID logo,
1) Department of Chemistry of Natural Compounds, National University of Pharmacy, Kharkiv, Ukraine,
2) Department of Pharmacognosy, National University of Pharmacy, Kharkiv, Ukraine
3) Department of Pharmacology and Prescription writing, Kharkiv National Medical University Kharkiv, Ukraine
4) Department of Pharmaceutical technologies, Faculty of pharmacy, Medical University of Varna, Bulgaria.

Qualitative composition and content of phenolic compounds in the liquid extract obtained from plum fruits have been studied. Five phenolic substances were found, as gallic acid, three hydroxycinnamic acids and rutin. The dominant substance was neochlorogenic acid (2320±42 mg/kg). Phenolic substances were identified in the extract and their amount determined by HPLC. Diuretic activity as diurnal spontaneous diuresis and forced diuresis, hypouricosemic and the membrane-stabilizing effects of plum liquid extract and its influence on the rheological properties of blood were studied.

Keywords: plum, fruits, extract, phenolic compounds, diuretic, hypouricosemic, membrane-stabilizing effect,

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Please cite this article as: Mohammed SB, Upyr TV, Olga M. Shapoval OM, Lenchyk LV, Georgiev K. Determination of phenolic compounds in Prunus domestica fruits extract and its pharmacological activity. J of IMAB. 2019 Apr-Jun;25(2):2589-2594. DOI: 10.5272/jimab.2019252.2589

Corresponding AutorCorrespondence to: Larysa Lenchyk, Chemistry of Natural Compounds Department, National University of Pharmacy; 53, Pushkinska str., Kharkiv 61002, Ukraine; E-mail: larysa.lenchyk@gmail.com

1. 1. Pharmaceutical encyclopedia. 2nd ed.: Chairman Ed. Council Chernykh V.P. Kiev: “MORION”; 2016: 1952. [in Ukrainian].
2. Qaiser J, Naveed A.The pharmacological activities of prunes: The dried Plums. J Med Plant Res. 2011; 5(9): 1508-1511.
3. Zagayko A, Senuyk I, Lenchyk L, Galimullin R. Study of antioxidant activity of the extract from plum ordinary leaves. Ukrainian biopharmaceutical journal. 2014; 1(30): 25-28. [in Ukrainian].
4. Kovaleva AM, Abdulkafarova ER. Phenolic compounds from Potentilla anserina. Chem Nat Compd.  2011 Jul;47(3):446-7. [Crossref]
5. Lenchyk LV. Determination of phenolic compounds in Prunus domestica leaves extract. Scripta Scientifica Pharmaceutica. 2015; 2(2):35-39. [Crossref
6. Upyr TV. The study of the organic acids in dry extract of Ledum palustre shoots. Ukrainian Biopharmaceutical Journal. 2016; 6(47):71-74.
7. Chen LJ, Hrazdina G. Structural aspects of anthocyanin-flavonoid complex formation and its role in plant color. Phytochemistry. 1981; 20(2):297-303. [Crossref]
8. McMurrough I, Hennigan GP, Loughrey MJ. Quantitative analysis of hop flavonols using high-performance liquid chromatography. J Agric Food Chem. 1982 Nov;30(6):1102-6. [Crossref]
9. Vovk G, Koshovyi O, Komissarenko A. Study of dry extract phenolic compounds of sage leaves, obtained by complex processing after tincture production. Collection of scientific works of staff members of NMAPE. 2014; 4: 237 - 40.
10. European convention for the protection of vertebrate animals used for experimental and other scientific purposes // Council of European. Strasbourg, 1986. No. 123. 51 р.
11. Experimental study of the toxic effects of potential medicinal products / Preclinical studies of medicinal products: [method. rivers] / V.M. Kovalenko, O.V. Stefanov, Yu.M. Maksimov, IM Trachtenberg. K.: Avicenna, 2001; 74-97. [in Ukrainian].
12. Shumskaya NI, Karamzina N.N. To the evaluation of the functional state of the kidneys in rats during industrial poisoning / Toxicology of new industrial chemicals. L.: Medicine, 1966. (8): 14-27. [in Russian]
13. Functional biochemistry / AL Zagayko, LM Voronina, MV Voloshenko et al. Kh. NUPh, 2010. 220 p Ukrainian.
14. Gozhenko AI, Kuksan NI, Pogorila IV Functional state of the kidneys in a chronic blockade of synthesis of nitric oxide in rats // Medical Chemistry. 2002; 4. (4): 65-8. [in Ukrainian]
15. Kamyshnikov VS Reference book on clinical and biochemical laboratory diagnostics. - Minsk “Belarus”, 2000: 268-281. [in Russian]
16. Bouayed J, Rammal H, Dicko A, Younos C, Soulimani R. Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects. J Neurol Sci. 2007 Nov 15;262(1-2):77-84. [PubMed] [Crossref].

Received: 29 November 2018
Published online: 27 June 2019

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