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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2019, vol. 25, issue2
Subject Area: Medicine
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DOI: 10.5272/jimab.2019252.2544
Published online: 08 May 2019
Original article
J of IMAB. 2019 Apr-Jun;25(2):2544-2548
MODULATORY EFFECT OF CANNABINOID LIGANDS ON THE ANXIETY-LIKE BEHAVIOR OF BULBECTOMIZED RATS
Miroslav D. Marinov1
, Margarita S. Velikova2, Roman E. Tashev3, Dobrinka K. Doncheva2,
1) Department of Physiology and Pathophysiology, Union of Pathophysiology, Faculty of Medicine, Medical University of Varna, Bulgaria.
2) Department of Physiology and Pathophysiology, Union of Physiology, Faculty of Medicine, Medical University of Varna, Bulgaria.
3 Department of Pathophysiology, Medical University of Sofia; Institute of Neurobiology, Bulgarian Academy of Sciences, Bulgaria.
ABSTRACT:
Purpose: The endocannabinoid system is considered a key regulatory system in anxiety behavior. The aim of the present study was to examine the effects of intracerebroventricularly (i.c.v.) injected cannabinoid ligands on the anxiety-like behavior of rats with a model of depression.
Material/Methods: The olfactory bulbectomized rat (OBX) is a well-established experimental model of depression. The OBX model exhibits neurochemical changes that are very similar to those seen in patients with depression. CB1 receptor agonist HU-210 and CB1 receptor antagonist SR 141716A were injected i.c.v. in OBX rats, and the anxiety-related behavior of the rats was measured in an elevated plus-maze (EPM) test.
Results: OBX rats showed an increased anxiety-like behavior at the EPM test. HU-210 produced an anxiolytic-like effect and alleviated the OBX-induced anxiety, while SR 141716A failed to produce effects on the behavior of OBX rats.
Conclusions: The results suggest that CB1 receptors may be involved in the modulation of anxiety-related behavior in OBX rats.
Keywords: Endocannabinoid system, Olfactory bulbectomy, Anxiety, Depression, HU-210, SR 141716A,
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Please cite this article as: Marinov MD, Velikova MS, Tashev RE, Doncheva DK. Modulatory effect of cannabinoid ligands on the anxiety-like behavior of bulbectomized rats. J of IMAB. 2019 Apr-Jun;25(2):2544-2548. DOI: 10.5272/jimab.2019252.2544
Correspondence to: Dr Miroslav Dimitrov Marinov, Department of Physiology and Pathophysiology, Medical University - Varna; 55, Marin Drinov str., 9002 Varna, Bulgaria; E-mail: miroslav.marinov@mu-varna.bg
REFERENCES:
1. Zuardi AW. History of cannabis as a medicine: a review. Rev Bras Psiquiatr. 2006 Jun;28(2):153-7. [PubMed] [Crossref]
2. Keyhani S, Steigerwald S, Ishida J, Vali M, Cerdб M, Hasin D, et al. Risks and Benefits of Marijuana Use: A National Survey of U.S. Adults. Ann Intern Med. 2018 Sep 4;169(5):282-290. [PubMed] [Crossref]
3. Zou S, Kumar U. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. Int J Mol Sci. 2018 Mar 13;19(3), 833.
4. Gorzalka BB, Hill MN, Hillard CJ. Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders. Neurosci Biobehav Rev. 2008 Aug;32(6):1152-60.
5. Ibarra-Lecue I, Pilar-Cuéllar F, Muguruza C, Florensa-Zanuy E, Díaz Á, Urigüen L, et al. The endocannabinoid system in mental disorders: Evidence from human brain studies. Biochem Pharmacol. 2018 Nov;157:97-107. [PubMed] [Crossref]
6. Morales-Medina JC, Iannitti T, Freeman A, Caldwell HK. The olfactory bulbectomized rat as a model of depression: The hippocampal pathway. Behav Brain Res. 2017 Jan 15;317:562-575. [PubMed] [Crossref]
7. Pellegrino L, A. Cushman. A Stereotaxic Atlas of the Rat Brain. AppletonCentury-Crofts, New York, USA, 1967.
8. Pellow S, Chopin P, File SE, Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods. 1985 Aug;14(3):149-67.
9. Moreira FA, Wotjak CT. Cannabinoids and anxiety. Curr Top Behav Neurosci. 2010;2:429-50.
10. Lisboa SF, Niraula A, Resstel LB, Guimaraes FS, Godbout JP, Sheridan JF. Repeated social defeat-induced neuroinflammation, anxiety-like behavior and resistance to fear extinction were attenuated by the cannabinoid receptor agonist WIN55,212-2. Neuropsychopharmacology. 2018 Aug;43(9):1924-1933.
11. Alteba S, Korem N, Akirav I. Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood. Learn Mem. 2016 Jun 17;23(7):349-58
12. Haj-Mirzaian A, Amini-Khoei H, Haj-Mirzaian A, Amiri S, Ghesmati, Zahir M, et al. Activation of cannabinoid receptors elicits antidepressant-like effects in a mouse model of social isolation stress. Brain Res Bull. 2017 Apr;130:200-210. [PubMed] [Crossref]
13. Kinden R, Zhang X. Cannabinoids & Stress: impact of HU-210 on behavioral tests of anxiety in acutely stressed mice. Behav Brain Res. 2015 May 1;284:225-30.
14. Sartim AG, Guimarгes FS, Joca SR. Antidepressant-like effect of cannabidiol injection into the ventral medial prefrontal cortex-Possible involvement of 5-HT1A and CB1 receptors. Behav Brain Res. 2016 Apr 15;303:218-27.
15. Hajizadeh Moghaddam A, Bigdellu R, Fatemi Tabatabaei SR, Roohbakhsh A. Cannabinoid system of the lateral septum in the modulation of anxiety-like behaviors in rats. Arch Iran Med. 2013 Dec;16(12):711-6.
16. Liu B, Liu J, Wang M, Zhang Y, Li L. From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder. Front Cell Neurosci. 2017 Sep 28;11:305.
17. Bambico FR, Katz N, Debonnel G, Gobbi G. Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex. J Neurosci. 2007 Oct 24;27(43):11700-11.
18. Tzavara ET, Davis RJ, Perry KW, Li X, Salhoff C, Bymaster FP, Witkin JM, Nomikos GG. The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions. Br J Pharmacol. 2003 Feb;138(4):544-53. [PubMed] [Crossref]
19. Sagredo O, Ramos JA, Fernandez-Ruiz J, Rodriguez ML, de Miguel R. Chronic Delta9-tetrahydrocannabinol administration affects serotonin levels in the rat frontal cortex. Naunyn Schmiedebergs Arch Pharmacol. 2006 Jan;372(4):313-7. [PubMed] [Crossref]
20. Hill MN, Sun JC, Tse MT, Gorzalka BB. Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment. Int J Neuropsychopharmacol. 2006 Jun;9(3):277-86. [PubMed] [Crossref].
Received: 25 September 2018
Published online: 08 May 2019