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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2019, vol. 25, issue1
Subject Area: Medicine
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DOI: 10.5272/jimab.2019251.2414
Published online: 14 March 2019
Review article
J of IMAB. 2019 Jan-Mar;25(1):2414-2418
FERROPTOSIS AND ITS POTENTIAL ROLE IN CARDIOVASCULAR DISEASES
Yavor Kashlov
, Maria Dimova,
Department of Internal Medicine, UMHAT St. Marina, Faculty of Medicine, Medical University, Varna, Bulgaria.
ABSTRACT:
Iron (Fe) is the fourth most common element in the earth's crust, and plays a significant role in the human body.It is important for cell survival due toits involvement in the transport of oxygen, in DNA biosynthesis, adenosine triphosphate (ATP) synthesis, as well as an auxiliary factor of various proteins in the tricarboxylic acid cycle (TCA). It has also been found that iron is closely related to the onset and progression of various cancers and disturbances in its metabolism can stimulate the growth of tumor cells. In addition, divalent iron significantly accelerates the lipid peroxidation of saturated fatty acids.
Keywords: Ferroptosis, adenosine triphosphate (ATP), erastin, cell death, apoptosis, necrosis,
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Please cite this article as: Kashlov Y, Dimova M. Ferroptosis and its potential role in Cardiovascular diseases. J of IMAB. 2019 Jan-Mar;25(1):2414-2418. DOI: 10.5272/jimab.2019251.2414
Correspondence to: Yavor Kashlov, First Clinic of Cardiology, Department of Internal Medicine, Universiy Hospital St. Marina, Varna; 1, Hr. Smirnensky blvd., Varna, Bulgaria; E-mail: javork@abv.bg
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Received: 20 December 2018
Published online: 14 March 2019