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Publisher: Peytchinski Publishing
ISSN: 1312-773X (Online)
Issue: 2017, vol. 23, issue 2
Subject Area: Medicine - Toxicology
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DOI: 10.5272/jimab.2017232.1575
Published online: 31 May 2017
Original article
J of IMAB 2017 Apr-Jun;23(2):1575-1578
ACUTE EXOGENOUS INTOXICATIONS WITH ORGANOPHOSPHORUS PESTICIDES: DURATION OF THE HOSPITAL TREATMENT AND CLINICAL CRITERIA FOR PROGNOSIS
Petko Marinov1,4, Snezha Zlateva1,4, Dobri Ivanov2, Georgi Bonchev1
, Yulichka Sabeva4, Kaloyan Georgiev3, Ivaylo Vazharov5,
1) Clinic for Intensive Treatment of Acute Intoxications and Toxicoallergies, Naval Hospital – Varna, Military Medical Academy, Bulgaria
2) Department of Biology, Faculty of Pharmacy, Medical University – Varna, Bulgaria
3) Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University – Varna, Bulgaria
4) Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University – Varna, Bulgaria
5) Clinic of Internal Diseases, Naval Hospital – Varna, Military Medical Academy, Bulgaria.
ABSTRACT:
Purpose: Several criteria have been suggested to estimate the intoxication severity, yet so far no system of clinical criteria has been developed to determine the duration of hospitalisation. The forecast is linked to the influence of the extended corrected QT interval and GCS (Glasgow Coma Scale) on the frequency of the developing acute pulmonary insufficiency and lethality. The average duration of hospital treatment is also crucial. First of all, it is determined by the intoxication severity and lasts from 3 to 26 days. The aim of this study is to develop an individual forecast about the duration of hospitalisation for patients suffering from acute exogenous intoxication with organophosphorus pesticides (OPP).
Materials/Methods: The subjects are 160 patients. We use statistical regression analysis to study the significance of 5 of the most typical clinical indicators of organophosphorus intoxication on the duration of hospitalisation: type of conscience, presence of spasms, pulmonary oedema, shock and multi-organ insufficiency syndrome (MOIS). To forecast the treatment length, we obtain simplified mathematical expressions in the form of score estimates.
Results: The significance of the clinical indicators “MOIS”, “conscience” and “spasm” has been confirmed. A forecast matrix that gives the opportunity to forecast the personal duration of hospital treatment for each patient has been built.
Keywords: organophosphates, acute poisoning, duration of hospital treatment, prognosis,
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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Marinov P, Zlateva S, Ivanov D, Bonchev G, Sabeva Y, Georgiev K, Vazharov I. Acute exogenous intoxication with organophosphorus pesticides: duration of the hospital treatment and clinical criteria for prognosis. J of IMAB. 2017 Jan-Mar;23(2):1575-1578. DOI: 10.5272/jimab.2017232.1575
Correspondence to: Georgi Bonchev, PhD, Head, Laboratory of Analytical Toxicology, Military Medical Academy, Naval Hospital – Varna; 3, Hristo Smirnenski Blvd., 9010 Varna, Bulgaria; E-mail: toxilab.varna@abv.bg
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Received: 20 March 2017
Published online: 31 May 2017