Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2016, vol. 22, issue 4
Subject Area: Medicine
Pages: 1389-1391
DOI: 10.5272/jimab.2016224.1389
Published online: 19 December 2016

J of IMAB 2016 Oct-Dec;22(4):1389-1391
Ivaylo Vazharov1 Corresponding Autor, Hristo Bozov2, Snezha Zlateva3, Georgi Bonchev3,
1) Clinic of Internal diseases, Naval Hospital – Varna, Military Medical Academy, Bulgaria
2) Clinic of Anaesthesiology, Marine and Intensive medicine, Naval Hospital – Varna, Military Medical Academy, Bulgaria
3) Clinic for Intensive Treatment of Acute Intoxications and Toxicoallergies, Naval Hospital – Military Medical Academy, Bulgaria.

This is a report of 30 years old woman suffering from Crohn’s disease who had a good clinical response to Infliximab (Remicade) at first, but during the treatment after 5 months she lost response. After receiving Adalimumab (Humira) clinical remission was reached on the day 20. The case demonstrates rapid response to adalimumab in incidence of losing efficacy to another tumor necrotic factor - alpha (TNF- alpha) antagonist.

Key words: Crohn's disease, TNF- alpha inhibitors, adalimumab, infliximab,

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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Vazharov I, Bozov H, Zlateva S, Bonchev G. Adalimumab induction and maintaining remission for Crohn’s disease in patient who lost response to Infliximab. Case report. J of IMAB. 2016 Oct-Dec;22(4):1389-1391. DOI: 10.5272/jimab.2016224.1389.

Correspondence to: Assoc. Prof. Ivaylo Vazharov, MD, PhD, Naval Hospital – Varna, Military Medical Academy; 3, Chr. Smirnenski St, Varna 9010, Bulgaria; E-mail:

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Received: 10 October 2016
Published online: 19 December 2016

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