Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2016, vol. 22, issue 4
Subject Area: Medicine
Pages: 1352-1354
DOI: 10.5272/jimab.2016224.1352
Published online: 20 October 2016

J of IMAB 2016 Oct-Dec;22(4):1352-1354
Petko Marinov1, Snezha Zlateva1, Georgi Bonchev1 Corresponding Autor, Dobri Ivanov1, Marieta Yovcheva1, Kaloyan Georgiev3,
1) Clinic for Intensive Treatment of Acute Intoxications and Toxicoallergies, Naval Hospital – Varna, Military Medical Academy, Bulgaria
2) Department of Biology, Faculty of Pharmacy, Medical University – Varna, Bulgaria
3) Department of preclinical and clinical sciences, Faculty of Pharmacy, Medical University – Varna, Bulgaria.

Purpose: Methanol (CH3OH) is a monohydric alcohol, vastly used both in housekeeping and industry. Although the acute methanol intoxications are rare, they may include life-threatening symptoms, substantial lethality and negative consequences such as neurological disorders and vision damage. Aim of the work is to conduct a retrospective study on the acute methanol intoxications within Varna region for a 10-year period (2006-2015).
Material/Methods: This study covers 39 patients of the Clinic for Intensive Treatment of Acute Intoxications and Toxicoallergies at Naval Hospital – Varna, all of which had their diagnosis confirmed, including gas chromatography methods.
Results: Methanol intoxication prevalence showed male/female ratio close to 2.9:1. The major part of the cases concerned economically active population, the age group of 25-60 being the most affected. In all instances an oral methanol intake has been involved. Death occurred in 14 cases (35.9%)..

Key words: methanol, acute intoxications, alcohol dehydrogenase, formaldehyde, formic acid,

- Download FULL TEXT /PDF 526 KB/
Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Marinov P, Zlateva S, Bonchev G, Ivanov D, Yovcheva M, Georgiev K. ACUTE METHANOL INTOXICATIONS – A CHALLENGE FOR CLINICAL TOXICOLOGY. J of IMAB. 2016 Oct-Dec;22(4):1352-1354
OI: 10.5272/jimab.2016224.1352.

Correspondence to: Georgi Bonchev, PhD, Head, Laboratory of Analytycal Toxicology, Military Medical Academy, Naval Hospital – Varna; 3, Chr. Smirnenski St, Varna 9010, Bulgaria; E-mail:

1. Rietjens SJ, de Lange DW, Meulenbelt J. Ethylene glycol or methanol intoxication: which antidote should be used, fomepizole or ethanol? Neth J Med. 2014 Feb;72(2):73-9. [PubMed]
2. Marraffa JM, Cohen V, Howland MA. Antidotes for toxicological emergencies: a practical review. Am J Health Syst Pharm. 2012 Feb;69(3):199-212. [PubMed]
3. Barbera N, Indorato F, Spitareli A, Bosco A, Carpinteri M, Busardo FP, et al. A singular case of survival after acute methanol poisoning: toxicological and neurological findings. Am J Forensic Med Pathol. 2014 Dec; 35(4):253-5. [PubMed]
4. Nand L, Chander S, Kashyap R, Gupta D, Jhobta A. Methyl alcohol poisoning: a manifestation of typical toxicity and outcome. J Assoc Physicians India. 2014 Aug;62(8):756-9. [PubMed]
5. Kim HJ, Na JY, Lee YJ, Park JT, Kim HS. An autopsy case of methanol induced intracranial hemorrhage. Int J Clin Exp Pathol. 2015 Oct 1;8(10):13643-6. [PubMed]
6. McMartin K, Jakobsen D, Hovda KE. Antidotes for poisoning by alcohols that form toxic metabolites. Br J Clin Pharmacol. 2016 Mar;81(3):505-15. [PubMed]
7. Sabeva Y, Marinov P, Zlateva S, Koleva M. Denaturated alcohol as a frequent source of methanol intoxication. J of IMAB. 2007; 13(1):98 [CrossRef]
8. Rogaczewska A, Kobza-Sindlewska K, Krakowiak A, Piekarska-Wijatkowska A. [Acute alcohol poisoning among patients in Toxicology Unit, Nofer Insitute of Occupational Medicine in the period of time 2007-2012.] [in Polish] Przegl Lek. 2014;71(9):479-83. [PubMed]
9. Desai T, Sudhalkar A, Vyas U, Khamar B. Methanol poisoning: predictors of visual outcomes. JAMA Ophthalmol. 2013 Mar;131(3):358-64. [PubMed]
10. Celik S, Karaperli M, Kandemir E, Ucar F, Kantarci MN, Gurler M, et al. Fatal ethyl and methyl alcohol-related poisoning in Ankara: A retrospective analysis of 10720 cases between 2001 and 2011. J Forensic Leg Med. 2013 Apr;20(3):151-4. [PubMed]
11. Zakharov S, Kurcova I, Navratil T, Salek T, Komarc M, Pelclova D. Is the measurement of serum formate concentration useful in the diagnostics of acute methanol poisoning? A prospective study of 38 patients. Basic Clin Pharmacol Toxicol. 2015 May;116(5):445-51. [PubMed]
12. Hubenova A, Stankova E, Paskalev K. [Poisonings and antidote treatment]. [in Bulgarian] Sofia,Art L. 2008; 68-70.
13. Kraut JA. Diagnosis of toxic alcohols: limitations of present methods. Clin Toxicol (Phila). 2015; 53(7):589-95. [PubMed]
14. Lachance P, Mac-Way F, Desmeules S, de Serres SA, Julien AS, Douville P, et al. Prediction and validation of hemodialysis duration in acute methanol poisoning. Kidney Int. 2015 Nov;88(5):1170-7. [PubMed]
15. Roberts DM, Yates C, Megarbane B, Winchester JF, Maclaren R, Gosselin S, et al. Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: a systematic review and consensus statement. Crit Care Med. 2015 Feb;43(2):461-72. [PubMed]
16. Thanacoody RH, Gilfillan C, Bradberry SM, Davies J, Jackson G, Vale AJ, et al. Management of poisoning with ethylene glycol and methanol in the UK: a prospective study conducted by the National Poisons Information Service (NPIS). Clin Toxicol (Phila). 2016 Feb;54(2):134-40. [PubMed]
17. Zakharov S, Pelclova D, Urban P, Navratil T, Diblik P, Kuthan P, et al. Czech mass methanol outbreak 2012: epidemiology, challenges and clinical features. Clin Toxicol (Phila). 2014 Dec;52(10):1013-24. [PubMed]
18. Zakharov S, Pelclova D, Navratil T, Belacek J, Komarc M, Eddleston M, et al. Fomepizole versus ethanol in the treatment of acute methanol poisoning: Comparison of clinical effectiveness in a mass poisoning outbreak. Clin Toxicol (Phila). 2015 Jun;53(8):797-806. [PubMed]
19. Shadnia S, Rahimi M, Soltaninejad K, Nilli A. Role of clinical and paraclinical manifestations of methanol poisoning in outcome prediction. J Res Med Sci. 2013 Oct;18(10):865-9. [PubMed]
20. Coulter CV, Farquhar SE, McSherry CM, Isbister GK, Duffull SB. Methanol and ethylene glycol acute poisoning – predictors of mortality. Clin Toxicol (Phila). 2011 Dec;49(10):900-6. [PubMed]
21. Giovanetti F. Methanol poisoning among travellers to Indonesia. Travel Med Infect Dis. 2013 May-Jun;11(3):190-3. [PubMed]
22. Paasma R, Hovda KE, Tikkerberi A, Jacobsen D. Methanol mass poisoning in Estonia: outbreak in 154 patients. Clin Toxicol (Phila). 2007;45(2):152-7. [PubMed].

Received: 27 May 2016
Published online: 20 October 2016

back to Online Journal