Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2016, vol. 22, issue 3
Subject Area: Medicine
Pages: 1221-1225
DOI: 10.5272/jimab.2016223.1221
Published online: 25 July 2016

J of IMAB 2016 Jul-Sep;22(3):1221-1225
Filka Georgieva Corresponding Autor,
Department of Dermatology and Venereology, Faculty of Medicine, Medical University- Varna, Bulgaria

Background Lichen Simplex Chronicus (LSC) is a common extremely pruritic dermatoses affecting seriously the wellbeing of patients. Although the diagnosis is easily confirmed the therapy is still a challenge for specialists.
The aim of the study was to update the epidemiology of LSC.
Objective and Methods To assess the tendencies in distribution of LSC were analyzed data collected from registers of Medical Centre “St. Anna” Varna from January 2007 till July 2015. Data include reports of 39968 outpatients with different skin problems. The model of the study was retrospective and investigates the total morbidity, gender distribution, age distribution, peak condition and place of the disease in the structure of selected chronic recurrent dermatoses with negative impact on quality of life. Data were collected and processed after obtaining written permission from the leadership of MC “St. Anna" Varna.
Results. The overall frequency of LSC was 4.04%. It increased from 2.59% (2007) to 4.62% (2015). Results show a tendency of rejuvenation of LSH with two peaks of morbidity: over 65 years of age 11.87% and second in the range 25-30 years -10.77%.The the ratio female / male is established to 1.2: 1.The distribution analysis shows the prevalence of LSC in winter season – January 5.14%, February – 4.57% and low morbidity in summer mouths - July 1.92% and August 0.66%.  (p = 0.001) The distribution of LSC was compared with that of several skin diseases with a chronic course and a negative influence on the quality of life of patients. Results show increasing of LSC from 3.36% (2008) to 4.55% (2014) (p = 0.001).
Conclusion This is the first study in our country, which aims to update the epidemiology of LSC.

Key words: Epidemiology, Lichen simplex chronicus, morbidity,

- Download FULL TEXT /PDF 947 KB/
Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Georgieva F. Current Epidemiology of Lichen Simplex Chronicus. J of IMAB. 2016 Jul-Sep;22(3):1221-1225. DOI:

Correspondence to: Filka Georgieva, 74b, Tzar Assen str., 9002 Varna Bulgaria; E-mail:

1. 1. James WD, Berger TG, Elston DM. Andrew's Diseases of the Skin. International edition. 12th Ed., Clinical Dermatology.  Elsevier. May 2015. [Internet]
2. Lotti T, Buggiani G, Prignano F; Prurigo nodularis and lichen simplex chronicus. Dermatol Ther. 2008 Jan-Feb;21(1):42-6. [PubMed] [CrossRef]
3. Martin-Brufau R, Corbalan- Berna J, Ramirez-Andreo A, Brufau-Redondro C, Liminana- Gras R. Personality differences between patiens with lichen simplex chronicus and normal population: A study of pruritus. Eur J Dermatol. 2010 May-Jun;20(3):359-563. [PubMed] [CrossRef]
4. McKoy K. Lichen Simplex Chronicus (Neurodermmatitis). Merck Manual, 2012 [Internet]
5. Rajalakshmi R, Thappa DM, Jaisankar TJ, Nath AK. Lichen simplex chronicus of anogenital region: A clinico-etiological study. Indian J Dermatol Venereol Leprol. 011 Jan-Feb;77(1):28-36. [PubMed] [CrossRef]
6. Williams W, Steward A, von Muitus E, Cookson W, Anderson HR. Is eczema really on the increase worldwide? J Allergy Clin Immunol. 2008 Apr;121(4):947-54. [CrossRef]
7. Liao YH, Lin CC, Tsai PP, Shen WC, Sung FS, Kao CH Increased risk of lichen simplex chronicus in people with anxiety disorders:a nationwide population-based retrospective cohort study Br J Dermatol. 2014 Apr;170(4):890-894. [PubMed]
8. Shukla S, Mukherjee S. Lichen simplex chronicus during lithium treatment. Am J Psychiatry. 1984 Jul;141(7):909-10. [PubMed]
9. Khaitan BK, Sood A, Singh MK. Lichen simplex chronicus with a cutaneous horn. Acta Derm Venereol. 1999 May;79(3):243. [PubMed]
10. Cybulski M, Krajewska-Kulak E. Skin diseases among elderly inhabitants of Bialystok, Poland. Clin Interv Aging. 2015 Dec;10:1937–1943. [PubMed]
11. Grundmann SA, Stonder S.Evaluation of chronic pruritus in older patients. Aging Health. 2010 Feb:6(1):53-66. [CrossRef]
12. Schaefer H, Redelmeier TE. Skin Barrier: Principles of Percutaneous Absorbtion. Basel:Karger, 2006: 310-336
13. Rawlings AV, Harding CR. Moisturization and skin bappier function. Dermatol Ther. 2014 Feb; 17(Suppl 1):43-48. [PubMed] [CrossRef]
14. Rogers JS, Harding CR, Mayo A, Rawling AV. Stratum corneum lipids: the effect of aging and the seasons. Arch Derrmatol Res. 1996 Nov;288(12);765-770. [PubMed]
15. Boulter E, Estrach S, Errante A, Pons C, Cailleteau L, Tissot F, et al. CD98hc(SLC3A2) regulation of skin homeostasis wanes with age. J Exp Med. 2013 Jan;210(1):173-190. [PubMed] [CrossRef]
16. Slominski A, Zbytec B, Nikolakis G, Manna PR, Skobowiat C, Zmijewski M, at al. Steroidogenesis in the skin:Implication for local immune functions. J Steroid Biochem Mol Biol. 2013 Sept;137:107-123. [PubMed] [CrossRef]
17. Fang YX, He M, Lin JY, Ma KJ, Zhao H, Hong Z, et al. Suicidal drownings with psychiatric disorders in Shanghai: a retrospective study from 2010.1 to 2014.6. PLoS One. 2015 Apr 27;10(4):e0121050. [PubMed] [CrossRef].

Received: 14 May 2016
Published online: 25 July 2016

back to Online Journal