 |
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2015, vol. 21, issue 1
Subject Area: Medicine
Pages: 694-698
DOI: 10.5272/jimab.2015211.694
Published online: 10 February 2015
J of IMAB 2015 Jan-Mar;21(1):694-698
REPRODUCTIVE FACTORS AND COLORECTAL CANCER RISK. Case - control study.
Adriana Ruseva1
, Radka Lazarova1, Ilko Kosturkov1, Vesselina Ianachkova2, Stella Yordanova2, Zhivka Boneva2, Diana Nikolovska1.
1) Clinic of Gastroenterology, Medical Institute - Ministry of Interior, Sofia, Bulgaria
2) Department of Endocrinology, Medical Institute - Ministry of Interior, Sofia, Bulgaria
ABSTRACT:
Colorectal cancer is one of the most common cancers worldwide. The role of the female sex hormones in the etiology of the disease is very intriguing. Reproductive factors are surrogate measure of lifetime exposition to the sex hormones.
Purpose: Our aim is to investigate the association between the reproductive factors and colorectal carcinoma risk.
Materials and methods: We include 234 Bulgarian women in our study – 117 cases with colorectal cancer and the same number of healthy controls. Cases are divided into three groups according to the localization of the tumor. We conduct case-control study, using questionnaires about reproductive factors. We use the following statistical methods – descriptive, variational analysis, binary logistic regression.
Results: We observed that only the age at menopause is associated with colorectal cancer risk, and this factor has strongest protective effect in the proximal colon (95% CI - 0,051-0,781, OR – 0,200, p – 0,021).
Conclusion: Analyzing our data we observed that among Bulgarian women the only reproductive factor that show association with the risk of colorectal cancer is the age at menopause.
Key words: colorectal cancer, reproductive factors, risk factors, age at menopause,
- Download FULL TEXT /PDF 537 KB/
Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Ruseva A, Lazarova R, Kosturkov I, Ianachkova V, Yordanova S, Boneva Z, Nikolovska D. Reproductive factors and colorectal cancer risk. Case - control study. J of IMAB. 2015 Jan-Mar;21(1):694-698. doi: http://dx.doi.org/10.5272/jimab.2015211.694
Correspondence to: Dr. Adriana H. Ruseva, Clinic of Gastroenterology, Medical Institute - Ministry of Interior, Sofia; 79, Skobelev blvd., Sofia, Bulgaria; E-mail: dr_aruseva@abv.bg
REFERENCES:
1. Lo AC, Soliman AS, Khaled HM, Aboelyazid A, Greenson JK. Lifestyle, Occupational, and Reproductive Factors and Risk of Colorectal Cancer. Dis Colon Rectum. 2010 May;53(5):830–837. [PMC] [CrossRef]
2. Zervoudakis A, Strickler HD, Park Y, Xue X, Hollenbeck A, Schatzkin A, et al. Reproductive History and Risk of Colorectal Cancer in Postmenopausal Women. J Natl Cancer Inst. 2011 Mar;29(103):826–834. [PubMed] [CrossRef]
3. Nichols HB, Trentham-Dietz A, Hampton JM, Newcomb PA. Oral contraceptive use, reproductive factors, and colorectal cancer risk: findings from Wisconsin. Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1212–8. [PubMed]
4. Kune GA, Kune S, Watson LF. Children, age at first birth, and colorectal cancer risk. Data from the Melbourne Colorectal Cancer Study. Am J Epidemiol. 1989 Mar;129(3):533-42. [PubMed]
5. Li CY, Song B, Wang YY, Meng H, Guo SB, Liu LN, et al.Age at Menarche and Risk of Colorectal Cancer: A Meta-Analysis. PLoS ONE. 2013; 8(6):e65645. [CrossRef]
6. Lu Y, Oddsberg J, Martling A, Lagergren J. Reproductive History and Risk of Colorectal Adenocarcinoma. Epidemiology. 2014 Jul;25(4):595-604. [PubMed] [CrossRef]
7. Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, et al. Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women. Cancer Res. 2008 Jan;68(1):329-337. [PubMed] [CrossRef]
8. Tsilidis KK, Allen NE, Key TJ, Bakken K, Lund E, Berrino F, et al. Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition. Br J Cancer. 2010 Nov;103(11):1755-1759. [PubMed] [CrossRef]
9. Delellis Henderson K, Duan L, Sullivan-Halley J, Ma H, Clarke CA, Neuhausen SL, et al. Menopausal Hormone Therapy Use and Risk of Invasive Colon Cancer: The California Teachers Study. Am J Epidemiol. 2010 Feb;171(4):415-425. [PubMed] [CrossRef]
10. Akhter M, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S. Reproductive factors, exogenous female hormone use and colorectal cancer risk: the Japan Public Health Center-based Prospective Study. Eur J Cancer Prev. 2008 Nov;17(6):515-524. [PubMed] [CrossRef]
11. Endogenous Hormones and Breast Cancer Collaborative Group, Key TJ, Appleby PN, Reeves GK, Roddam AW. Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncol. 2010 Jun;11(6):530-542. [PubMed] [CrossRef]
12. Burkman RT. Reproductive hormones and cancer: ovarian and colon cancer. Obstet Gynecol Clin North Am. 2002 Sep;29(3):527-40. [PubMed]
13. Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Tateno H, et al. Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors. Cancer Res. 2009 Feb;69(3):914–922. [PubMed] [CrossRef]
14. Enmark E, Huikko MP, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, et al. Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab. 1997 Dec;82(12):4258–4265. [PubMed] [CrossRef]
15. Rudolph A, Toth C, Hoffmeister M, Roth W, Herpel E, Schirmacher P, et al. Colorectal Cancer Risk Associated with Hormone Use Varies by Expression of Estrogen Receptor-β. Cancer Res. 2013; June 1;73(11):3306-15. [PubMed] [CrossRef].
Received: 14 November 2014
Published online: 10 February 2015