Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2013, vol. 19, book 4
Subject Collection: Oral and Dental Medicine
Pages: 388-391
DOI: 10.5272/jimab.2013194.388
Published online: 15 October 2013

J of IMAB 2013; 19(4):388-391
ORAL SIGNS OF LEUKEMIA AND DENTAL MANAGEMENT – literature data and case report.
Elitsa G. Deliverska 1Corresponding Autor, Assya Krasteva2.
1) Department of Oral and Maxillofacial surgery,
2) Department of Oral Imaging and Oral Diagnostic,
Faculty of Dental Medicine, Medical University Sofia, Bulgaria.

A The oral signs and symptoms may be reflect a undetected serious systemic diseases. Depending on the oral manifestation the dentists and physicians make attention and focusing on specific diagnoses. In some cases oral involvement may be frequently herald the onset of the disease which requires the dentists to better knowledge of changes in the oral cavity.
In the oral cavity local symptoms and findings of leukemia include paleness of the oral mucosa with gingival bleeding that develops into painless gingival hyperplasia, petechiae, hemorrhages, and ulcerative necrotic lesions
Because of their clinical importance, all such lesions deserve the full attention of the dental doctors. The aim is to evaluate in detail the oral complications of leukemia at initial presentation and present a clinical case of 54 old female with oral manifestation as initial signs of the disease.

Key words: oral manifestation; leukemia; dentist; management;

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Please cite this article as:
Deliverska EG, Krasteva A. Oral signs of leukemia and dental management – literature data and case report. J of IMAB. 2013; 19(4):388-391. doi: 10.5272/jimab.2013194.388.

Correspondence to: dr Elitsa Deliverska, Department of Oral and Maxillofacial surgery, Faculty of Dental Medicine, 1, Georgi Sofiyski blvd., 1431 Sofia, Bulgaria; e-mail:

1. Franch AM, Esteve CG, Pérez, GS. Oral manifestations and dental management of patient with leukocyte alterations. J Clin Exp Dent. 2011;3(1):e53-59. [CrossRef]
2. Demirer S, Özdemir H, Şencan M, Marakoglu I. Gingival Hyperplasia as an Early Diagnostic Oral Manifestation in Acute Monocytic Leukemia: A Case Report. Eur J Dent. 2007 Apr;1(2):111–114. [PubMed]
3. Greenberg MS, Glick M, Ship JA. (editors.) Burket’s Oral Medicine. 11th edition. Hamilton. BC Decker inc. 2008; 400-403.
4. Wu J, Fantasia JE, Kaplan R. Oral manifestations of acute myelomonocytic leukemia: a case report and review of the classification of leukemias. J Periodontol. 2002 Jun;73(6):664-668. [PubMed] [CrossRef]
5. Weckx LL, Hidal LB, Marcucci G. Oral manifestations of leukemia. Ear Nose Throat J. 1990 May;69(5):341-2, 345-346. [PubMed]
6. Bruch JM, Nathaniel ST.  Clinical Oral Medicine and Pathology. Humana Press. 2010; [CrossRef]
7. Silva BA, Siqueira C, Castro P, Araújo SS, Volpato LE. Oral manifestations leading to the diagnosis of acute lymphoblastic leukemia in a young girl. J Indian Soc Pedod Prev Dent. 2012 Apr-Jun;30(2):166-168. [PubMed] [CrossRef]
8. Dean AK, Ferguson JW, Marvan ES. Acute leukaemia presenting as oral ulceration to a dental emergency service. Aust Dent J. 2008 Sep;48(3):195-7. [PubMed] [CrossRef]
9. Güzeldemir E, Toygar HU, Koçer NE, Kizilkilic E.  The periodontal management of a patient with acute myelomonocytic leukemia. Nobel Med. 2012 Jan-Apr;8(1):110-113. [Full text]
10. Chapple IL, Saxby MS, Murray JA. Gingival hemorrhage, myelodysplastic syndromes, and acute myeloid leukemia. A case report. J Periodontol. 1999 Oct;70(10):1247-1253. [PubMed] [CrossRef]
11. Cooper CL, Loewen R, Shore T. Gingival hyperplasia complicating acute myelomonocytic leukemia. J Can Dent Assoc. 2000 Feb;66(2):78-9. [PubMed]
12. Khera P, Zirwas MJ, English JC 3rd. Diffuse gingival enlargement. J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):491-499. [PubMed] [CrossRef]
13. Barrett AP. Gingival lesions in leukemia. A classification. J Periodontol. 1984 Oct;55(10):585-588. [PubMed] [CrossRef]
14. Orbak R, Orbak Z. Oral condition of patients with leukemia and lymphoma. J Nihon Univ Sch Dent. 1997 Jun;39(2):67-70. [PubMed]
15. Hou GL, Huang JS, Tsai CC. Analysis of oral manifestations of leukemia: a retrospective study. Oral Dis. 1997 Mar;3(1):31–38. [PubMed] [CrossRef]
16. Loudona JA, Colemanb, HJ, Allenc CM, Schifter M, Ng T, Al-Horani G. Rare oral manifestation of chronic myelogenous leukemia and its targeted therapy: A case report and literature review. Univers J Med Dent. 2012 Oct;1(7):79-85. [Full text]
17. Albuquerque MA, Migliari DA, Sugaya NN, Kuroishi M, Capuano AC, Sousa SO, et al. Adult T-cell leukemia/lymphoma with predominant bone involvement, initially diagnosed by its oral manifestation: A case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Sep;100(3):315–320. [PubMed] [CrossRef]
18. Bricker SL, Langlais RP, Miller CS. Oral Diagnosis, Oral Medicine, and Treatment Planning. 2nd edition. Philadelphia; Lea & Febiger. 1994.

Received: 20 July 2013
Published online: 15 October 2013

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