back to 2012, vol. 18, b. 3
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2012, vol. 18, book 3;
Subject Collection: Medicine
Page: 276-279
DOI: 10.5272/jimab.2012183.276
Published online: 29 August 2012

J of IMAB. 2012; 18(3):276-279
ASPECTS OF CYCLON AND BDNF GENE EXPRESSION IN SCHIZOPHRENIA PATIENTS
Trifon Chervenkov1, Rinaldo Shishkov2
1) Department Clinical Medical Sciences, Immunology laboratory
2) Department Psychiatry and Medical Psychology
Medical University - Varna, Bulgaria.


ABSTRACT:
The pathogenesis of the schizophrenic illness is still not fully elucidated. Many studies have been conducted revealing different aspects but may be the studies of greatest significance are studying the genetic aspects of expression of trophic factors and enzymes associated with nervous system development and plasticity. In this relation we aimed at measuring the Cyclon and BDNF genes expression in blood of patients suffering from schizophrenia and to test for correlation between them. Our result did not reveal correlation in spite of their connection with the disease.

Key words: schizophrenia, ccdc86, Cyclon, BDNF.

- Download FULL TEXT ( PDF 626 KB )
Please cite this article as: Chervenkov Tr, Shishkov R. Aspects of Cyclon and BDNF Gene Expression in Schizophrenia Patients. J of IMAB. 2012; 18(3):276-279. doi: 10.5272/jimab.2012183.276

REFERENCES:
1. Agartz I, Sedvall GC, Terenius L, Kulle B, Frigessi A, Hall H, et al. BDNF gene variants and brain morphology in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):513–523. [PubMed ] [CrossRef ]
2. Angelucci F, Brenè S, Mathé AA. BDNF in schizophrenia, depression and corresponding animal models Mol Psychiatry. 2005 Apr;10(4):345–352. [PubMed ] [CrossRef ]
3. Chen X, Wang X, Hossain S, O'Neill FA, Walsh D, van den Oord E, et al. Interleukin 3 and schizophrenia: the impact of sex and family history. Mol Psychiatry. 2007 Mar;12(3):273-82. [PubMed] [CrossRef ]
4. Chen Q, Wang X, O'Neill FA, Walsh D, Fanous A, Kendler KS, et al. Association study of CSF2RB with schizophrenia in Irish family and case - control samples. Mol Psychiatry. 2008 Oct;13(10):930-8. [PubMed ] [CrossRef ]
5. Dempster E, Toulopoulou T, McDonald C, Bramon E, Walshe M, Filbey F, et al. Association between BDNF val66 met genotype and episodic memory. Am J Med Genet B Neuropsychiatr Genet. 2005; Apr 5;134B(1):73–75. [PubMed ] [CrossRef ]
6. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity - dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003 Jan 24;112(2):257–269. [PubMed ] [CrossRef ]
7. Gorski JA, Zeiler SR, Tamowski S, Jones KR. Brain - derived neurotrop hic factor is required for the maintenance of cortical dendrites. J Neurosci. 2003 Jul 30;23(17):6856–6865. [PubMed ]
8. Hattori M, Kunugi H, Akahane A, Tanaka H, Ishida S, Hirose T, et al. Novel polymorphisms in the promoter region of the neurotrophin - 3 gene and their associations with schizophrenia. Am J Med Genet. 2002 Apr 8;114(3):304−309. [PubMed ] [CrossRef ]
9. Ho BC, Milev P, O’Leary DS, Librant A, Andreasen NC, Wassink TH: Cognitive and magnetic resonance imaging brain morphometric correlates of brain - derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Arch Gen Psychiatry. 2006 Jul;63(7):731–740. [PubMed ]
10. Hoshino А, Fujii H. Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. FEBS Lett. 2007 March 6; 581(5):975–980. [PubMed ] [CrossRef ]
11. Lencz T, Morgan TV, Athanasiou M, Dain B, Reed CR, Kane JM, et al. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry. 2007 Jun;12(6):572-80. [PubMed] [CrossRef]
12. Lu B. BDNF and activity - dependent synaptic modulation. Learn Mem. 2003 Mar-Apr;10(2):86–98. [PubMed] [CrossRef]
13. Singh M, Meyer EM, Simpkins JW. The effect of ovariectomy and estradiol replacement on brain - derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague−Dawley rats. Endocrinology 1995 May 1;136(5):2320−2324. [PubMed] [CrossRef]
14. Saint Fleur S, Hoshino A, Kondo K, Egawa T, Fujii H. Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood. 2009 Aug 13;114(7):1355-65. [PubMed] [CrossRef]
15. Smith MA, Makino S, Kvetnansky R, Post RM. Stress and glucocorticoids affect the expression of brain - derived neurotrophic factor and neurotrophin - 3 mRNAs in the hippocampus. J Neurosci. 1995 Mar;15(3 Pt 1):1768−1777. [PubMed]
16. Szekeres G, Juhasz A, Rimanoczy A, Keri S, Janka Z. The C270T polymorphism of the brain - derived neurotrophic factor gene is associated with schizophrenia. Schizophr Res. 2003 Dec 1;65(1):15--18. [PubMed] [CrossRef]
17. Szeszko PR, Lipsky R, Mentschel C, Robinson D, Gunduz-Bruce H, Sevy S, et al. Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation. Mol Psychiatry. 2005 Jul;10(7):631–636. [PubMed] [CrossRef]
18. Xu B, Zang K, Ruff NL, Zhang YA, McConnell SK, Stryker MP, et al. Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron. 2000 Apr;26(1):233-245. [PubMed] [CrossRef]
19. http://en.wikipedia.org/wiki/CD95 .

Accepted for publication: 22 May 2012
Issue published online: 29 August 2012

back to Online Journal