|Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2004, vol. 10, book 1
Subject Collection: Medicine
Online date: October 19, 2004
J of IMAB 2004; 10(1):45-46
TREATMENT OF DERMATOPHYTE ONYCHOMYCOSIS WITH TERBINAFINE (LAMISIL) PULSE THERAPY
Department of Dermatology and Venereology, Medical University, Pleven, Bulgaria
Terbinafine is the most active currently available antidermatophyte agent with fungicidal action. The aim of the present study was to assess the efficacy of terbinafine pulse therapy in the treatment of dermatophyte nail infections. Seven patients (two with fingernail, four with toenail and one with mixed onychomycosis) have been treated with 500 mg terbinafine daily for one week per month. The duration of the treatment was four months for toenail and three months for fingernail onychomycosis. At the end of the follow-up period (six months after discontinuation of treatment) 6 out of 7 patients (87%) were mycologically cured. In conclusion, pulse terbinafine therapy is an effective regimen for the treatment of dermatophyte nail infections.
Key words: onychomycosis, terbinafine, pulse therapy.
- Download FULL TEXT (PDF - 144 KB)
Please cite this article as: Valkova S. Treatment of dermatophyte onychomycosis with terbinafine (Lamisil) pulse therapy. J of IMAB. 2004; 10(1):45-46; DOI:10.5272/jimab.2004101.45
1. Crawford F, Young P, Godfrey C et al. Oral treatments for toenail onychomycosis. A systematic review. Arch Dermatol 2002;138:811-816.
2. De Doncker P, Decroix J, Pierard G et al. Antifungal pulse therapy for onycho-mycosis. A pharmacokinetic and pharmacodynamic investigation of monthly cycles of 1-week pulse therapy with itraconazole. Arch Dermatol 1996;132(1):34-41.
3. Faegermann J, Zehender H, Millerioux L. Levels of terbinafine in plasma, stratum corneum, dermis-epidermis (without stratum corneum), sebum, hair and nails during and after 250 mg terbinafine orally once daily for 7 and 14 days. Clin Exp Dermatol 1994; 19:121-126.
4. Gupta AK, Lynde CW, Konnikov N. Single-blind, randomized, prospective study of sequential itraconazole and terbinafine pulse compared with terbinafine pulse for the treatment of toenail onychomycosis. J Am Acad Dermatol 2001;44:485-491.
5. Munro CS, Shuster S. The route of rapid access of drugs to the distal nail plate. Acta Derm Venereol (Stockh) 1992; 72:387-388.
6. Ryder NS, Favre B. Antifungal activity and mechanism of action of terbinafine. Rev Contemp Pharmacother 1997; 8:275-288.
7. Ryder NS, Leither I. In vitro activity of terbinafine; an update. J Dermatol Treat 1998; 9( Suppl 1):S23-28.
8. Tosti A, Piraccini BM, Stinchi C et al. Treatment of dermatophyte nail infections: an open randomized study comparing intermittent terbinafine therapy with continuous terbinafine treatment and intermittent itraconazole therapy. J Am Acad Dermatol 1996; 34:595-600.
back to Online Journal