|Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2004, vol. 10, book 1
Subject Collection: Medicine
Online date: October 19, 2004
J of IMAB 2004; 10(1):38-41
SERUM-CONCENTRATIONS OF Dehydroepyandrosterone-sulfate IN MEN WITH ANDROGENETIC ALOPECIA
Ani Tsvetanova1, Dimitar Gospodinov1, Miroslav Donchev2
1) Department of Dermatology and Venereology, 2) Clinical center of nuclear medicine, Medical University, Pleven, Bulgaria
Androgenetic alopecia (AA) is considered as a genetically determinate androgen (DHT)-dependent disorder. Theoretically Dehydroepyandrosterone-sulfate (DHEA-S) is the first main metabolite in the androgen metabolism.
The aim of the study was to determine the serum-levels of DHEA-S (DHEA-S(s)) in patients with AA and the possible correlation between clinical stage of AA and DHEA-S(s).
Forty-four men (37 with male pattern baldness and 7 healthy controls) aged 19 to 55 had DHEA-S(s) measured. Determination of the hormone was performed by standard radioimmunoassay. Only nine of the men with AA showed high levels of DHEA-S(s). In 3 of the patients were detected a boundary high levels of DHEA-S(s). No correlation between the clinical stage of AA and DHEA-S(s) -levels was established. There was relationship only between increase of the age and decrease of the concentrations of DHEA-S(s).
In contrast to previous studies, in our investigation, no elevation of DHEA-S(s) in men with AA was found. Our results indirect support the current understanding of the importance of some follicular enzymes (STS, 3-beta-HSD, 17-beta-HSD etc.) that could increase the amount of the alternative DHT-sources in AA, as well as the theory for the “endocrinology of hair follicle”.
Key words: androgenetic alopecia, male pattern baldness, serum-levels of DHEA-S.
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Please cite this article as: Tsvetanova A, Gospodinov D, Donchev M. SERUM-CONCENTRATIONS OF Dehydroepyandrosterone-sulfate IN MEN WITH ANDROGENETIC ALOPECIA. J of IMAB. 2004; 10(1):38-41; DOI: 10.5272/jimab.2004101.38
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