back to 2008, vol. 14, b. 1

Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2008, vol. 14, book 1
Subject Collection: Medicine
Page: 72-75
DOI: 10.5272/jimab.14-1-2010.72
Online date: October 07, 2008

J of IMAB 2008; 14(1)72-75
SNEDDON’S SYNDROME
Valentin Valtchev1, Virginia Simeonova2, Dimitar Gospodinov1, Ivelina Yordanova1,Valentina Dimitrova1, Verka Pavlova1, E. Konova4, Savelina Popovska3, Boyko Stamenov2
1) Department of Dermatology and Venereology, 2) Department of Neurology, 3) Department of General and Clinical Pathology, 4) Department of Immunology, Medical University – Pleven, Bulgaria

ABSTRACT:
Sneddon’s syndrome is usually characterized by the association of an ischemic cerebrovascular disease and a widespread livedo reticularis. The incidence of Sneddon syndrome is 4/1000 000. We present 42-year-old woman with livedo reticularis, recurrence ischaemic cerebrovascular accidents, two repetitive miscarriages and positive anti-2GPi antibodies. Skin biopsy specimens reveal inflammatory changes of small- to medium-sized arteries and subendothelial proliferation and fibrosis. The diagnosis Sneddon syndrome is confirmed by skin biopsy, and MR evidence.
We suggest that anti-2GPi antibodies may be pathophysiologically related to the clinical manifestation observed in some patients with Sneddon syndrome.

Key words: Sneddon syndrome, livedo reticularis, ischemic cerebrovascular disease.

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Please cite this article as: Valtchev V, Simeonova V, Gospodinov D, Yordanova I, Dimitrova V, Pavlova V, Konova E, Popovska S, Stamenov B. SNEDDON’S SYNDROME. J of IMAB 2008; 14(1):72-75. DOI: 10.5272/jimab.14-1-2010.72

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