back to 2008, vol. 14, b. 1

Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2008, vol. 14, book 1
Subject Collection: Medicine
Page: 3-5
DOI: 10.5272/jimab.14-1-2010.3
Online date: May 22, 2008

J of IMAB 2008; 14(1):3-5
Galya I. Gancheva1ORCID logo email, Maria Atanasova1, Tzvetan Lukanov2, Penka Ilieva1
1) Department of Infectious Diseases, Epidemiology, Parasitology, and Tropical Medicine, Medical University, Pleven, Bulgaria
2) Sector of Clinical Immunology, Medical University, Pleven, Bulgaria

Differential count of leucocytes and six lymphocyte populations and subpopulations were investigated by flow cytometry in fourteen cases with leptospirosis. Marked granulocytosis and lymphopenia were found in 100%. The percentage of the monocytes was significantly decreased (mean 6,65%; 0,7 to 14,0%; sd 5,49). Immunophenotypization of lymphocyte populations and subpopulations by flow cytometry was revealed prevalent tendencies for decreasing of the number of total T-lymphocytes, T-helpers, T-suppressors, T-helpers/T-suppressors index; increasing of the number of the activated T-lymphocytes, subpopulation of NK cells (CD3-/ CD16+56+), and B-lymphocyte. These data are suggested that cell-mediated immunity plays a role in later stages of the diseases.

Key words: leptospirosis, immunogenesis, flow cytometry, lymphocyte subpopulations, dysregulation,

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Please cite this article as:
Gancheva GI, Atanasova M, Lukanov Tz., Ilieva P. FLOWCYTOMETRY IN LEPTOSPIROSIS. J of IMAB 2008; 14(1):3-5. DOI: 10.5272/jimab.14-1-2010.3

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