head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2020, vol. 26, issue4
Subject Area: Medicine
-
DOI: 10.5272/jimab.2020264.3436
Published online: 17 November 2020

Original article

J of IMAB. 2020 Oct-Dec;26(4):3436-3442
TREATMENT OF PROBLEMATIC SKIN WOUNDS BASED ON THE PLATELET-RICH PLASMA METHOD. OUR OWN ALGORITHMS FOR APPLICATION
Tsvetan Sokolov1ORCID logo Corresponding Autoremail, Anelya Manukova2ORCID logo, Vihar Kovachev3ORCID logo, Mancho Kovachev3ORCID logo,
1) Orthopedics and traumatology clinic, UMBAL Kanev, Ruse, Bulgaria.
2) Department of Electronics, University of Ruse, Ruse, Bulgaria.
3) Clinic of Orthopedics and Traumatology, Medical Faculty, Medical University Pleven, Bulgaria.

ABSTRACT:
OBJECTIVE: The objective of this paper is to present the application of our own algorithms for prevention and treatment of problematic skin wounds (PSW) by using the platelet-rich plasma (PRP) based on the first study on PRP application carried out in Bulgaria.
MATERIAL AND METHODS: The study was carried out at the Clinic of Orthopedics and Traumatology, UMBAL Kanev Ruse, for a period of 84 months - from February 2009 to September 2016. A total of 83 patients with PSW have been treated with platelet-rich plasma. Scores introduced by Cancela AM are used for the assessment of the respective wound. Each of these scores is used for assessing specific wound parameters.
RESULTS: Our own algorithms for prevention and treatment of PSW by PRP increase the percentage of successfully cured wounds. Prevention algorithm of applying PRP ensures that a high percentage of acute skin wounds will not turn into PSW. The proposed algorithms for prevention and treatment of PSW by applying PRP are an effective and safe way to reduce the uncured complicated skin wounds and ensure the subsequent normal life of patients. They also ensure more predictable skin healing.
CONCLUSION: Our own algorithms for prevention and treatment of PSW by PRP increase the percentage of successfully cured wounds. The proposed algorithms for prevention and treatment of PSW by applying PRP are an effective and safe way to reduce the uncured complicated skin wounds and ensure the subsequent normal life of patients.

Keywords: problematic skin wounds, platelet-rich plasma, algorithms for prevention and treatment,

pdf - Download FULL TEXT /PDF 5732 KB/
Please cite this article as: Sokolov T, Manukova A, Kovachev V, Kovachev M. Treatment of Problematic Skin Wounds Based on The Platelet-Rich Plasma Method. Our Own Algorithms for Application. J of IMAB. 2020 Oct-Dec;26(4):3436-3442. DOI: 10.5272/jimab.2020264.3436

Corresponding AutorCorrespondence to: Dr Tsvetan V. Sokolov, Clinic of Orthopedics and Traumatology, UMHAT Kanev, Ruse, Bulgaria; 2, Nezavisimost str., 7002 Ruse, Bulgaria; E-mail: sokolovi2001@abv.bg

REFERENCES:
1. Papanas N, Maltezos E. Growth factors in the treatment of diabetic foot ulcers: new technologies, any promises? Int J Low Extrem Wounds. 2007 Mar;6(1):37-53. [PubMed]
2. Clark M. Just the Facts. Number 1. Pressure ulcers. Welsh Wound Network. 2010. [Internet]
3. Hristov V. [Over 100 000 Bulgarians suffer from wounds that do not heal!] blitz.bg. 23 January 2014. [in Bulgarian] [Internet]
4. Shoham Y, Krieger Y, Silberstein E, Bogdanov-BerezovskyA, Regev E, Weissman O, et al. Negatively charged microspheres for the treatment of problematic wounds & patients. EWMA. 2014; poster 235.
5. Sokolov T, Manukova A, Karakoleva S, Valentinov B, Petrova N. Analysis of the results of applying the method Platelet-rich plasma (PRP) for the treatment of problematic skin wounds. J of IMAB. 2017 Jan-Mar;23(1):1460-1465. [Crossref]
6. Lindholm C, Searle R. Wound management for the 21st century: combining effectiveness and efficiency. Int Wound J. 2016 Jul;13 Suppl 2:5-15. [PubMed]
7. Crovetti G, Martinelli G, Issi M, Barone M, Guizzardi M, Campanati B, et al. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci. 2004 Apr;30(2):145-51. [PubMed]
8. Gottrup F, Jшrgensen B. Maggot debridement: an alternative method for debridement. Eplasty. 2011; 11:e33. [PubMed]
9. Cugar R. Foreword I. In: Platelet-Rich Plasma. Regenerative Medicine: Sports Medicine, Orthopedic, and Recovery of Musculoskeletal Injuries. Editors: Lana JFSD, Santana MHA, Belangero WD, Luzo ACM. Springer-Verlag Berlin Heidelberg. 2014. p.5-6 [Crossref]
10. Smith R, Gassmann C, Campbell M. Platelet-rich plasma: properties and clinical applications. JLGH. 2007;2(2):72-78.
11. Cancela AM, Lana JF, Annichino-Bizzachi JM, Belangero WD, Luzo ACM. Use of Platelet-Rich Plasma (PRP) in Treating Chronic Wounds. In: Lana JF, Shimojo AA, Belangero WD, Malheiros Luzo A. (eds.), Platelet-Rich Plasma. Lecture Notes in Bioengineering. Springer-Verlag Berlin, Heidelberg. 2014. p.281-288. [Crossref]
12. Lazarov В, S. Karakoleva S. Using GAS syntax for education in Mathematics. In: Higher education in Bulgaria and the Europe 2020 strategy, International business school, Botevgrad; 2011. p.914-921.
13. Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing. 2013 Jun 13;10(1):23. [PubMed]
14. Sarvajnamurthy S, Suryanarayan S, Budamakuntala L, Suresh D. Autologous Platelet Rich Plasma in Chronic Venous Ulcers: Study of 17 Cases. J Cutan Aesthet Surg. 2013 Apr;6(2):97-9. [PubMed]
15. Picard F, Hersant B, Bosc R, Meningaud J-P. Should we use platelet-rich plasma as an adjunct therapy to treat “acute wounds,” “burns,” and “laser therapies”: A review and a proposal of a quality criteria checklist for further studies. Wound Repair Regen. 2015 Mar-Apr;23(2):163-70. [PubMed]
16. Martin P, Nunan R. Cellular and molecular mechanisms of repair in acute and chronic wound healing. BrJ Dermatol. 2015 Aug;173:370–378. [PubMed]
17. Vandenkerkhof EG, Hopman WM, Carley ME, Kuhnke JL, Harrison MB. Leg ulcer nursing care in the community: a prospective cohort study of the symptom of pain. BMC Nurs. 2013 Feb 6;12:3. [PubMed]
18. Anitua Е, Alonso R, Girbau C, Aguirre JJ, Muruzabal F, Orive G. Antibacterial effect of plasma rich in growth factors (PRGF-Endoret) against Staphylococcus aureus and Staphylococcus epidermidis strains. Clin Exp Dermatol. 2012 Aug;37(6):652-7. [PubMed]
19. Tran TD-X, Le PT-B, Pham PV. Diabetic foot ulcer treatment by activated platelet rich plasma: a clinical study. Biomed Res Ther. 2014;1(2):37-42.
20. Frykberg RG, Banks J. Challenges in the Treatment of Chronic Wounds. Adv Wound Care (New Rochelle). 2015 Sep 1;4(9):560-582. [PubMed] [Crossref].

Received: 20 November 2019
Published online: 17 November 2020

back to Online Journal