head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing
ISSN: 1312-773X (Online)
Issue: 2018, vol. 24, issue2
Subject Area: Dental Medicine
-
DOI: 10.5272/jimab.2018242.1963
Published online: 02 April 2018

Case reports

J of IMAB. 2018 Apr-Jun;24(2):1963-1971
A CONTEMPORARY NON-INVASIVE METHOD FOR ASSESSING ORAL PRECANCEROUS LESIONS
Nikolay V. Nikolov Corresponding Autoremail, Elka Popova, Georgi Tomov,
Department of Periodontology, division of oral pathology, Faculty of Dental Medicine, Medical University - Plovdiv, Bulgaria.

ABSTRACT:
Purpose: With the advance of the modern technologies, the identification of dysplastic changes in the oral mucosa on a molecular level seems to have transferred into the dental office. With the new methods, however, new responsibilities and problems arise. The current review is an attempt to present the advantages and disadvantages of the clinical technologies used for early diagnostics of the oral precancerous lesions.
Materials and Methods: This study is based on an extensive literature review and personal clinical experience with these contemporary evaluating methods of oral precancerous lesions.
Results: The results from the pathohistological evaluation reveal stratified squamous epithelium with pronounced parabasal hyperplasia, disturbed maturation and loss of polarity of the basal cells. The latter demonstrates hyperchromatic polymorphic nuclei and single mitotic figures in half of the epithelial thickness. The morphological data points to a moderate epithelial dysplasia.
Conclusion: The loss of autofluorescence seems to be the most promising non-invasive method for identification of epithelial dysplasia in the oral cavity. The presence of some non-dysplastic lesions, which can also be non-fluorescent, i.e. produce “false negative” results, is one of the disadvantages of this method. Despite that most modern technologies are practical and convinient, they should be approached with a critical eye and should not be used as single and independent diagnostic means but only as an adjunct to the established classical methods of diagnostics.

Keywords: Oral precancerous, lesions, leukoplakia, erythroplakia,

pdf - Download FULL TEXT /PDF 3361 KB/
Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Nikolov NV, Popova E, Tomov G. A contemporary non-invasive method for assessing oral precancerous lesions. J of IMAB. 2018 Apr-Jun;24(2):1963-1971. DOI: 10.5272/jimab.2018242.1963

Corresponding AutorCorrespondence to: Nikolay Veselinov Nikolov, Department of Periodontology, Oral Pathology Department, Faculty of Dental Medicine, Medical University, Plovdiv; 3, Hristo Botev Blvd., 4000 Plovdiv, Bulgaria; E-mail: dr_n.nikolov@abv.bg,

REFERENCES:
1. Baillie M, Simms E. Queries and responses from the Medical Committee of the Society for Investigating the Nature and Cure of Cancer. Edinburgh Med Surg J. 1806; 2:382-9.
2. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. 3rd edition. Saunders, Elsevier. 11th June 2008 Chapter 2.
3. Paget J. Cancer following ichthyosis of the tongue. Trans Clin Soc Lond. 1870; 3:88-90.
4. Rossie KM, Guggenheimer J.  Thermally induced A nicotine stomatitis: a case report. Oral Surg Oral Med Oral Pathol. 1990 Nov;70(5):597-599. [PubMed]
5. Arnaud F, Bewley D, Farwell G. Oral leukoplakia and oral cavity squamous cell carcinoma. Clinics in Dermatology. 2017 Sep-Oct;35(5):461-467. [PubMed] [CrossRef]
6. Bouquot JE, Gorlin RJ. Leukoplakia, lichen planus and other oral keratoses in 23,616 white Americans over the age of 35 years. Oral Surg Oral Med Oral Pathol. 1986 Apr;61(4):373-81. [PubMed]
7. Speight PM, Farthing PM, Bouquot JE. The pathology of oral cancer and pre cancer revisited. CurrDiag Path 1996 Sep;3 (3):165-176
8. Napier SS, Speight PM. Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med. 2008 Jan;37(1):1-10. [PubMed] [CrossRef]
9. Warnakulasuriya S, Reibel J., Bouquot J., Dabelsteen E. Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. J of Oral Pathol and Med. 2008; 37 (3): 127-133 10. Warnakulasuriya S, Bouquot JE, Reibel J, Dabelsteen E. Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. J Oral Pathol Med. 2008 Mar;37(3):127-133. [PubMed] [CrossRef]
11. Hsue SS, Wang WC, Chen CH, Lin CC, Chen YK, Lin LM. Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a follow-up study based in a Taiwanese hospital. J Oral Pathol Med. 2007 Jan;36(1):25-9. [PubMed] [CrossRef]
12. Bouquot JE, Ephros H. Erythroplakia: the dangerous red mucosa. Pract Perio Aesth Dent. 1995 Aug;7(6):59-67. [PubMed]
13. Villa A, Woo SB. Leukoplakia--A Diagnostic and Management Algorithm. J Oral Maxillofac Surg. 2017 Apr;75(4):723-734. [CrossRef]
14. Reibel J. Prognosis of oral premalignant lesions: Significance of clinical, histopathological and molecular biological characteristics.Crit Rev Oral Biol Med. 2003; 14(1):47-62. [PubMed]
15. Holmstrup P, Vedtofte P, Reibel J, Stoltze K. Oral premalignant lesions: is biopsy reliable? J Oral Path Med. 2007 May;36(5):262-6. [PubMed] [CrossRef]
16. Grillone, GA, Wang Z, Krisciunas GP, Tsai AC, Kannabiran, VR, Pistey RW, et al. The color of cancer: Margin guidance for oral cancer resection using elastic scattering spectroscopy. Laryngoscope. 2017 Sep;127 Suppl 4:S1–S9. [PubMed] [CrossRef]
17. Trullenque-Eriksson A, Muñoz-Corcuera M,Campo-Trapero J, Cano-Sánchez J, Bascones-Martínez A. Analysis of new diagnostic methods in suspicious lesions of the oral mucosa. Med Oral Patol Oral Cir Bucal. 2009 May;14(5):E210-6. [PubMed]
18. Goodson ML, Smith DR, Thomson PJ. Efficacy of oral brush biopsy in potentially malignant disorder management. J Oral Pathol Med. 2017 Nov;46(10):896–901. [PubMed] [CrossRef]
19. Kerr AR, Sirois DA, Epstein JB. Clinical evaluation of chemiluminescent lighting: an adjunct for oral mucosal examinations. J Clin Dent. 2006; 17(3):59-63. [PubMed]
20. Cicciù M, Herford AS, Cervino G, Troiano G, Lauritano F, Laino L. Tissue Fluorescence Imaging (VELscope) for Quick Non-Invasive Diagnosis in Oral Pathology. J Craniofac Surg. 2017 Mar;28(2):e112–e115. [PubMed] [CrossRef]
21. Oh ES, Laskin DM. Efficacy of the ViziLitesystem in the identification of oral lesions. J Oral Maxillofac Surg. 2007 Mar;65(3):424-6. [PubMed] [CrossRef]
22. Farah CS, Bhatia N, Lalla Y, Vu A, John K, Gupta V, et al. Advances in Early Detection and Diagnostic Adjuncts in Oral Cavity Cancer. In: Contemporary Oral Oncology. Kuriakose MA. (eds). Springer, Cham. 2017; Chapter 9:pp. 355-421. [CrossRef]
23. https://www.denmat.com/Oral%20Hygiene/Lesion%20Detection/ViziLite/Pack
24. Betz CS, Mehlmann M, Rick K, Stepp H, Grevers G, Baumgartner R, et al. Autofluorescence imaging and spectroscopy of normal and malignant mucosa in patients with head and neck cancer. Lasers Surg Med. 1999; 25(4):323-34. [PubMed] [CrossRef]
25. Svistun E, Alizadeh-Naderi R, El-Naggar A, Jacob R, Gillenwater A, Richards-Kortum R. Vision enhancement system for detection of oral cavity neoplasia based on autofluorescence. Head Neck. 2004 Mar;26(3):205-15. [PubMed] [CrosRef]
26. Mayevsky A, Rogatsky GG. Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies. Am J Physiol Cell Physiol. 2007 Feb;292(2):C615-40. [PubMed] [CrossRef]
27.  Speight PM, Epstein J, Kujan O, Lingen MW, Nagao T, Ranganathan K, et al. Screening for oral cancer--a perspective from the Global Oral Cancer Forum. Oral Surg Oral Med, Oral Pathol Oral Radiol. 2017 Jun;123(6):680-687. [PubMed] [CrossRef]
28. Roblyer D, Kurachi C, Stepanek V, Williams MD, El-Naggar AK, Lee JJ, et al. Objective detection and delineation of oral neoplasia using autofluorescence imaging.Phila Pa). 2009 May;2(5):423-431. [PubMed] [CrossRef]..

Received: 09 November 2017
Published online: 02 April 2018

back to Online Journal