head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing
ISSN: 1312-773X (Online)
Issue: 2018, vol. 24, issue1
Subject Area: Medicine
DOI: 10.5272/jimab.2018241.1936
Published online: 22 March 2018

Review article

J of IMAB. 2018 Jan-Mar;24(1):1936-1940
Irina I. IvanovaORCID logo Corresponding Autoremail,
Clinic of Gastroenterology, Department of Internal Diseases, Medical University – Varna, Bulgaria.

The burden of advanced chronic liver disease is increasing worldwide, despite the recent advances in the management of chronic hepatitis viral infections. The abdominal ultrasound is the only approved method for surveillance of patients with cirrhosis, a premalignant condition for hepatocellular cancer (HCC). Although alpha fetoprotein has been known as a tumour marker for HCC, it is not commonly used for screening due to suboptimal sensitivity and specificity. There is a need to introduce a novel biomarker for definition of HCC in early stage and for prognostic and therapeutic response assessment. A review of the current evidences, encouraging the use of glypican-3 in management of patients with cirrhosis and HCC is presented.

Keywords: hepatocellular carcinoma, cirrhosis, biomarkers, glypican-3,

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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Ivanova II. May Glypican-3 be a novel biomarker and potential therapeutic target in hepatocellular cancer? J of IMAB. 2018 Jan-Mar;24(1):1936-1940. DOI: 10.5272/jimab.2018241.1936

Corresponding AutorCorrespondence to: Irina Ivanova Ivanova, Clinic of Gastroenterology, UMHAT “St. Marina”, 1, Hristo Smirnenski blvd., 9010 Varna, Bulgaria; E-mail: irina.ivanova@mu-varna.bg,

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Received: 08 January 2018
Published online: 22 March 2018

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