back to 2013, vol. 19, b. 1
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2013, vol. 19, book 1;
Subject Collection: Medicine
Page: 387-390
DOI: 10.5272/jimab.2013191.387
Published online: 01 April 2013

J of IMAB. 2013; 19(1):387-390;
Deyan N. DavidovCorresponding Autor
Department of Chemotherapy, Oncological center, Medical University, Pleven, Bulgaria.

Objective: Single agent Docetaxel is a standard therapy for patients with non- small cell lung cancer after the failure of platinum- containing regimens. The aim of this study was to explore the efficacy and safety of Docetaxel monotherapy as second- line chemotherapy in pretreated patient with inoperable non- small cell lung cancer. Methods: From January 2005 to May 2008 thirty- six consecutive patients with locally advanced or metastatic morphologically proven stage IIIB/ IV non- small cell lung cancer entered the study after failure of previous platinum- based regimens. Treatment schedule consist of Docetaxel 75 mg/m2 administered every three weeks with repetition after 21 days with Dexamethasone premedication. Results: Overall response rate, median time to progression and median survival was 16,6 %, 4,5 months and 5,6 months respectively. The main hematological toxicity was neutropenia. Conclusions: That data suggest that single agent Docetaxel remain reasonable choices for the chemotherapy in pretreated patients with non- small cell lung cancer.

Key words: Docetaxel, Non- small cell lung cancer, Second- line chemotherapy.

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Please cite this article as:
Davidov DN. Single Agent Docetaxel as Second- Line Chemotherapy for Pretreated Patients with Recurrent Non- Small Cell Lung Cancer. J of IMAB. 2013; 19(1):387-390. DOI: 10.5272/jimab.2013191.387.

Correspondence to: Dr. Deyan Nikolov Davidov, Department of Chemotherapy, Oncological Center, Medical University Pleven; 1, "St. Kliment Ohridsky" Str., 5000 Pleven, Bulgaria.

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Accepted for publication: 23 October 2012
Published online: 01 April 2013

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