back to 2012, vol. 18, b. 3
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2012, vol. 18, book 3;
Subject Collection: Medicine
Page: 284-286
DOI: 10.5272/jimab.2012183.284
Published online: 28 September 2012

J of IMAB. 2012; 18(3):284-286
Mariana Arnaoudova,
Department of psychiatry, Medical University-Varna, Bulgaria; Third psychiatric Clinic, University hospital “St. Marina”- Varna, Bulgaria.

Persistent genital arousal (PGAD) is an unusual, rarely diagnosed but a real problem for some women which causes considerable physical and psychological distress. It is characterized by physiological signs of sexual arousal that persist despite the absence of sexual desire. A number of theories have been proposed and various psychological and medical treatments have been used to treat this condition with varying success.
The problem is even more serious with elderly women. In our clinical practice we have met a number of patients with such complains, which we have discussed mostly in terms of depression, panic disorder or SSRI’s application.
In our paper we discuss some diagnostic and therapeutic issues and present a case of a 71 years old woman, who experienced distinct symptoms of PGAD for nearly 10 years. She was treated with a number of antidepressants and benzodiazepines without effect. Olanzapine 5 mg at bed time was administered. A good therapeutic response was achieved from the same evening and was held at the hospital stay and afterwards.

Key words: PGAD, diagnosis, treatment.

- Download FULL TEXT ( PDF 539 KB )
Please cite this article as: Arnaoudova M. PERSISTANT GENITAL AROUSAL DISORDER IN ELDERLY WOMEN: A CASE STUDY. J of IMAB. 2012; 18(3):284-286. doi: 10.5272/jimab.2012183.284

1. Leiblum SR, Nathan SG. Persistent sexual arousal syndrome: A newly discovered pattern of female sexuality. J Sex Marital Ther. 2001 Jul-Sep;27(4):365-80. [CrossRef] [PubMed]
2. Leiblum SR, Nathan S. Persistent sexual arousal syndrome in women: A not uncommon but little recognized complaint. Sex Rel Ther 2002; 17:191-198.
3. Leiblum SR. Arousal disorders in women: complaints and complexities. Med J Aust. 2003 Jun 16; 178(12):638-40. [PubMed]
4. Leiblum SR. Persistent genital arousal disorder: What it is and what it isn’t. Contemporary Sexuality, July 2006.
5. Goldmeier D, Mears A, Hiller J, Crowley T; BASHH Special Interest Group for Sexual Dysfunction. Persistent genital arousal disorder: A review of the literature and recommendation for management. Int J STD AIDS. 2009 Jun; 20(6):373-7. [CrossRef], [PubMed]
6. Leiblum S, Seehuus M, Goldmeier D, Brown C. Psychological, Medical, and Pharmacological Correlates of Persistent Genital Arousal Disorder. J Sex Med. 2007 Sep;4(5):1358–66. [PubMed] [CrossRef]
7. Brotto LA, Bitzer J, Laan E, Leiblum S, Luria M. Women’s sexual desire and arousal disorders. J Sex Med. 2010 Jan;7(1 Pt 2):586–614. [PubMed] [CrossRef]
8. Goldmeier D, Bell C, Richardson D. Withdrawal of selective serotonin reuptake imhibitors (SSRIs) may cayse increased atrial natriuretic peptide (ANP) and persistent sexual arousal in women? J Sex Med. 2006 Mar;3(2);376. [PubMed] [CrossRef]
9. Waldinger MD, de Lint GJ, Venema PL, van Gils AP, Schweitzer DH. Successful transcutaneous electrical nerve stimulation in two women with restless genital syndrome: The role of adelta- and C-nerve fibers. J Sex Med. 2010 Mar;7(3):1190–9. [PubMed] [CrossRef
10. Leiblum SR, Chivers ML. Normal and persistent genital arousal in women: New perspectives. J Sex Marital Ther<. 2007 Jul;33(4):357-73. [PubMed] [CrossRef]
11. Khan F, Spence VA, Kennedy G, Belch JJF. Prolonged acetylcholine-induced vasodilatation in the peripheral microcirculation of patients with chronic fatigue syndrome. Clin Physiol Func Imaging. 2003 Sep;23(5):282-5. [PubMed] [CrossRef]
12. Clayton A, Kornstein S, Prakash A, Mallinckrodt C, Wohlreich M. Changes in sexual functioning associated with doluxetine, esscitalopram and placebo in the treatment of patients with major depressive disorder. J Sex Med. 2007 Jul;4(4 Pt 1):917-29. [PubMed] [CrossRef]
13. Guiliano F, Rampin O, Allard J. Neurophysiology and pharmacology of female genital sexual response. J Sex Marital Ther. 2002; 28(Suppl. 1):101-121. [PubMed] [CrossRef]
14.  Philippsohn S, Kruger TH. Persistent Genital Arousal Disorder: Successful Treatment with Duloxetine and Pregabalin in Two Cases. J Sex Med. 2012 Jan;9(1):213-217. [PubMed] [CrossRef]
15.  Korda JB, Pfaus JG, Goldstein I. Persistent Genital Arousal Disorder: A Case Report in a Woman with Lifelong PGAD Where Serendipitous Administration of Varenicline Tartrate Resulted in Symptomatic Improvement. J Sex Med. 2009 May;6(5):1479-1486. [PubMed] [CrossRef].

Accepted for publication: 04 June 2012
Issue published online: 28 September 2012

back to Online Journal